LY75
LY75蛋白全稱為淋巴細(xì)胞抗原75，又名DEC-205或CD205，是C型凝集素受體家族成員。這種跨膜蛋白主要在樹突狀細(xì)胞表面富集，能高效識(shí)別病原體相關(guān)分子模式，通過(guò)內(nèi)吞作用將抗原物質(zhì)轉(zhuǎn)運(yùn)至溶酶體加工，隨后與MHC-II分子結(jié)合呈遞給CD4+T細(xì)胞，在啟動(dòng)適應(yīng)性免疫應(yīng)答中起核心作用。LY75表達(dá)異常與黑色素瘤、三陰性乳腺癌等惡性腫瘤進(jìn)展相關(guān)，高表達(dá)DEC-205的腫瘤細(xì)胞可能通過(guò)逃避免疫監(jiān)視促進(jìn)轉(zhuǎn)移。在感染性疾病中，HIV病毒可劫持該蛋白作為入侵宿主細(xì)胞的通道。基于其抗原呈遞特性，科研人員開發(fā)了抗DEC-205單克隆抗體偶聯(lián)NY-ESO-1腫瘤抗原的疫苗CDX-1401，該藥物已完成針對(duì)晚期實(shí)體瘤的Ⅰ/Ⅱ期臨床試驗(yàn)，數(shù)據(jù)顯示能顯著激活腫瘤特異性T細(xì)胞反應(yīng)。另有研究將其與TLR3配體聯(lián)合使用，增強(qiáng)抗病毒免疫效果，為新型免疫佐劑設(shè)計(jì)提供了方向。
熱銷產(chǎn)品
LY75 Antibody (CSB-PA013251ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: LY75 antibody IgG at 1.57μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 199, 216, 20, 210 kDa
Observed band size: 199 kDa
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA013251ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA013251ESR1HU at dilution of 1:100
LY75 Antibodies
LY75 for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA013251HA01MO | Ly75 Antibody | Mouse | ELISA |
LY75 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA947833 | LY75 Antibody | Human | ELISA,WB |
| CSB-PA009886 | LY75 Antibody | Human | WB, ELISA |
| CSB-PA171204 | LY75 Antibody | Human | ELISA,IHC |
| CSB-PA013251ESR1HU | LY75 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA013251ESR2HU | LY75 Antibody | Human | ELISA, IHC |
LY75 Proteins
LY75 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013251HU CSB-EP013251HU CSB-BP013251HU CSB-MP013251HU CSB-EP013251HU-B |
Recombinant Human Lymphocyte antigen 75 (LY75), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LY75 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013251MO CSB-BP013251MO CSB-MP013251MO CSB-EP013251MO-B |
Recombinant Mouse Lymphocyte antigen 75 (Ly75), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP013251MO | Recombinant Mouse Lymphocyte antigen 75 (Ly75), partial | E.coli |
LY75 Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013251MRG CSB-EP013251MRG CSB-BP013251MRG CSB-MP013251MRG CSB-EP013251MRG-B |
Recombinant Mesocricetus auratus Lymphocyte antigen 75 (LY75), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
