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LIFR

LIFR,即白血病抑制因子受體,別名LIF-R、CD118等。它來(lái)源于人類基因組,編碼一種屬于I型細(xì)胞因子受體家族的蛋白質(zhì)。LIFR通過(guò)與高親和力的轉(zhuǎn)換亞單位gp130結(jié)合形成受體復(fù)合物,介導(dǎo)白血病抑制因子的作用,后者是一種多功能細(xì)胞因子,參與成人和胚胎的細(xì)胞分化、增殖和存活。在生物學(xué)上,LIFR的突變與Schwartz-Jampel綜合征2型等疾病相關(guān),揭示了其在維持細(xì)胞正常功能和預(yù)防疾病中的重要作用。此外,LIFR還參與多種細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)過(guò)程,對(duì)細(xì)胞生長(zhǎng)、分化和凋亡等生理活動(dòng)具有廣泛影響。

熱銷產(chǎn)品

Recombinant Human Leukemia inhibitory factor receptor (LIFR), partial (Active) (CSB-MP012929HUi9)

驗(yàn)證數(shù)據(jù)

CSB-MP012929HUi9

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012929HUi9

Activity
Measured by its binding ability in a functional ELISA. Immobilized human LIF (CSB-MP012928HU) at 2 μg/ml can bind human LIFR, the EC50 is 11.68-15.52 ng/ml.

LIFR Antibody (CSB-PA012929LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA012929LA01HU

Immunofluorescence staining of A549 cells with CSB-PA012929LA01HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA012929LA01HU

Western Blot
Positive WB detected in: MCF7 whole cell lysate,Rat Brain tissue lysate
All lanes: LIFR antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 123 kDa
Observed band size: 123 kDa

LIFR Antibodies

LIFR for Homo sapiens (Human)

LIFR Proteins

LIFR Proteins for Homo sapiens (Human)

LIFR Proteins for Mus musculus (Mouse)

LIFR Proteins for Rattus norvegicus (Rat)

LIFR Proteins for Canis familiaris (Dog) (Canis lupus familiaris)