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LAMC2

LAMC2,即層粘連蛋白γ2鏈,它是由LAMC2基因編碼的蛋白質,在人體中發揮作用。LAMC2是一種細胞外基質蛋白,通過與細胞表面的高親和力受體結合,參與調節細胞的黏附、遷移和組織形成。其作用機制涉及與細胞外基質的其他組分相互作用,影響細胞的行為和組織結構的穩定性。LAMC2在多種生物學過程中具有重要作用,包括胚胎發育、組織再生和腫瘤發展。在信號通路方面,LAMC2與PI3K/AKT/mTOR等信號通路相關,通過這些通路調節細胞的增殖、侵襲和轉移。LAMC2的異常表達與多種疾病有關,包括腫瘤的發生和發展,其中在肝內膽管細胞癌(iCCA)中存在擴增和特異性高表達,可能成為腫瘤治療的潛在靶點。

熱銷產品

Recombinant Human Laminin subunit gamma-2 (LAMC2), partial (CSB-EP618803HU)

驗證數據

CSB-EP618803HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LAMC2 Antibody (CSB-PA618803LA01HU)

驗證數據

CSB-PA618803LA01HU

Western Blot
Positive WB detected in: Hela whole cell lysate
All lanes: LAMC2 antibody at 5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 131, 122 kDa
Observed band size: 140 kDa

CSB-PA618803LA01HU

IHC image of CSB-PA618803LA01HU diluted at 1:200 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA618803LA01HU

IHC image of CSB-PA618803LA01HU diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

LAMC2 Antibodies

LAMC2 for Homo sapiens (Human)

LAMC2 Proteins

LAMC2 Proteins for Homo sapiens (Human)

LAMC2 Proteins for Mus musculus (Mouse)

LAMC2 Proteins for Equus caballus (Horse)