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KRT8

KRT8,全稱為Keratin 8,是一種重要的細(xì)胞骨架蛋白,主要表達(dá)于上皮細(xì)胞的細(xì)胞質(zhì)中。該蛋白常見別名包括Cytokeratin-8 (CK-8)、Keratin-8 (K8)、Type-II keratin Kb8等。KRT8蛋白通常與KRT18蛋白形成異二聚體,共同參與構(gòu)成上皮細(xì)胞的中等大小細(xì)絲,維持細(xì)胞的形態(tài)和結(jié)構(gòu)穩(wěn)定性。KRT8蛋白在細(xì)胞信號傳導(dǎo)和細(xì)胞分化過程中也發(fā)揮著重要作用。KRT8蛋白的表達(dá)水平與多種疾病密切相關(guān),如肺癌、慢性阻塞性肺疾病、哮喘、肺囊性纖維化等。在肺癌中,KRT8蛋白的表達(dá)與腫瘤的發(fā)生、發(fā)展和轉(zhuǎn)移密切相關(guān)。針對KRT8蛋白的藥物研發(fā)已取得一定進(jìn)展,如抗KRT8抗體等,這些藥物有望成為治療相關(guān)疾病的新策略。

熱銷產(chǎn)品

Recombinant Human Keratin, type II cytoskeletal 8 (KRT8), partial (CSB-EP012574HU)

驗(yàn)證數(shù)據(jù)

CSB-EP012574HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KRT8 Recombinant Monoclonal Antibody (CSB-RA556953A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA556953A0HU

Immunofluorescence staining of Hela cell with CSB-RA556953A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA556953A0HU

Overlay Peak curve showing Hela cells stained with CSB-RA556953A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

KRT8 Antibodies

KRT8 for Homo sapiens (Human)

KRT8 for H, M, R

KRT8 Proteins

KRT8 Proteins for Homo sapiens (Human)