KLRB1
KLRB1，全稱“殺傷細(xì)胞凝集素樣受體亞家族B成員1”，別名CD161，是一種II型膜蛋白，主要表達(dá)于自然殺傷（NK）細(xì)胞和部分T細(xì)胞表面。CD161蛋白具有C型凝集素特征的結(jié)構(gòu)域，參與調(diào)節(jié)NK細(xì)胞和T細(xì)胞的免疫功能。在NK細(xì)胞中，CD161與其配體LLT1結(jié)合，抑制細(xì)胞毒性并調(diào)節(jié)細(xì)胞因子分泌。而在T細(xì)胞中，CD161可作為激活型受體，參與Th17細(xì)胞的分化和IL-17的分泌。CD161的表達(dá)受IL-12等細(xì)胞因子調(diào)控，并在免疫應(yīng)答中發(fā)揮重要作用。相關(guān)研究表明，CD161在腫瘤微環(huán)境中可作為治療靶點(diǎn)，通過阻斷CD161-LLT1結(jié)合增強(qiáng)NK細(xì)胞活性，或激活T細(xì)胞殺傷腫瘤細(xì)胞。目前，針對(duì)CD161的抗體和免疫檢查點(diǎn)抑制劑等藥物研發(fā)正在進(jìn)行中，有望為腫瘤治療提供新策略。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA249906(KLRB1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA249906(KLRB1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse kidney tissue, human fetal liver tissue, Primary antibody: CSB-PA249906(KLRB1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
KLRB1 Antibodies
KLRB1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005290 | KLRB1 Antibody | Human | WB, ELISA |
| CSB-PA249906 | KLRB1 Antibody | Human,Mouse | ELISA,WB,IHC |
KLRB1 Proteins
KLRB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP621524HU CSB-EP621524HU CSB-BP621524HU CSB-MP621524HU CSB-EP621524HU-B |
Recombinant Human Killer cell lectin-like receptor subfamily B member 1 (KLRB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
