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Your Good Partner in Biology Research

KLB

KLB(Klotho β),也稱為β-klotho,是一種跨膜蛋白,具有多個結構域,這些結構域在不同的活性環境中發揮著不同的功能。KLB在調節礦物質代謝、細胞信號傳導和衰老過程中起著重要作用。它與FGF23共同作用,影響磷酸鹽的重吸收和維生素D的活化,同時可能通過影響Wnt/β-catenin信號通路中的β-catenin穩定性來調節細胞增殖和分化。此外,KLB還可能與TGF-β家族成員相互作用,參與調節細胞外基質的合成和分解,影響組織修復和纖維化過程。KLB的異常表達或功能失調與多種疾病相關,包括慢性腎病、心血管疾病和衰老相關的疾病,使其成為生物醫學研究中的一個有前景的靶點。

熱銷產品

KLB Antibody (CSB-PA769815LA01HU)

驗證數據

CSB-PA769815LA01HU

IHC image of CSB-PA769815LA01HU diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA769815LA01HU

IHC image of CSB-PA769815LA01HU diluted at 1:200 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA769815LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA769815LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

KLB Antibodies

KLB for Homo sapiens (Human)

KLB Proteins

KLB Proteins for Homo sapiens (Human)

KLB ELISA Kit

KLB ELISA Kit for Homo sapiens (Human)