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Your Good Partner in Biology Research

KITLG

Kitlg,全稱為Kit Ligand,別名包括SCF、MGF、FPFH、DCUA等。它是一種由骨髓微環(huán)境中的基質(zhì)細(xì)胞產(chǎn)生的酸性糖蛋白,由兩個(gè)相同亞基非共價(jià)結(jié)合而成。Kitlg蛋白主要在造血過(guò)程中發(fā)揮作用,參與原始生殖細(xì)胞、神經(jīng)細(xì)胞發(fā)育以及卵泡發(fā)育等過(guò)程。其異常表達(dá)與多種疾病相關(guān),如家族性進(jìn)行性高色素沉著癥、神經(jīng)性耳聾、某些類型的癌癥等。在腫瘤微環(huán)境中,Kitlg蛋白的表達(dá)與腫瘤細(xì)胞的增殖、侵襲和轉(zhuǎn)移密切相關(guān),是癌癥治療中的潛在藥物靶點(diǎn)。目前,針對(duì)Kitlg蛋白的藥物研發(fā)主要集中在細(xì)胞因子治療和免疫治療領(lǐng)域,例如靶向Kitlg蛋白的單克隆抗體、JAK抑制劑等。這些藥物旨在通過(guò)抑制Kitlg蛋白的表達(dá)或活性,從而抑制腫瘤細(xì)胞的生長(zhǎng)和轉(zhuǎn)移,為癌癥患者提供新的治療選擇。

熱銷產(chǎn)品

Recombinant Human Kit ligand (KITLG), partial (Active) (CSB-MP002061HU1)

驗(yàn)證數(shù)據(jù)

CSB-MP002061HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP002061HU1

Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of MO7e cells is 1.813-3.203 ng/mL.

CSB-MP002061HU1

The purity of KITLG was greater than 95% as determined by SEC-HPLC

Recombinant Mouse Kit ligand (Kitlg), partial (Active) (CSB-MP012376MO1)

驗(yàn)證數(shù)據(jù)

CSB-MP012376MO1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012376MO1

Activity
Measured by its binding ability in a functional ELISA.Immobilized Mouse Kitlg at 2 μg/ml can bind Mouse Kit(CSB-MP012375MO). The EC50 is 15.57-20.95 ng/mL.

CSB-MP012376MO1

Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 1.691-11.94 ng/mL.

Recombinant Human Kit ligand (KITLG), partial (Active) (CSB-MP002061HU1i9)

驗(yàn)證數(shù)據(jù)

CSB-MP002061HU1i9

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP002061HU1i9

Activity
Measured by its binding ability in a functional ELISA.Immobilized Human KIT(CSB-MP012375HU1) at 2 μg/ml can bind Human KITLG. The EC50 is 0.6921-0.8551 ng/mL.

KITLG Recombinant Monoclonal Antibody (CSB-RA183183A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA183183A0HU

Western Blot
Positive WB detected in: PC-3 whole cell lysate(30μg), HT-29 whole cell lysate(30μg), K562 whole cell lysate(30μg), Hela whole cell lysate(30μg), A549 whole cell lysate(30μg)
All lanes: SCF antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 31 kDa
Observed band size: 40 kDa
Exposure time:1min40s

CSB-RA183183A0HU

IHC image of CSB-RA183183A0HU diluted at 1:100 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA183183A0HU

Overlay Peak curve showing 786-O cells stained with CSB-RA183183A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

KITLG Antibodies

KITLG for Homo sapiens (Human)

KITLG Proteins

KITLG Proteins for Ovis aries (Sheep)

KITLG Proteins for Felis catus (Cat) (Felis silvestris catus)

KITLG Proteins for Rattus norvegicus (Rat)

KITLG Proteins for Mus musculus (Mouse)

KITLG Proteins for Mustela vison (American mink) (Neovison vison)

KITLG Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

KITLG Proteins for Capra hircus (Goat)

KITLG Proteins for Equus caballus (Horse)

KITLG Proteins for Gallus gallus (Chicken)

KITLG Proteins for Bos taurus (Bovine)

KITLG Proteins for Sus scrofa (Pig)

KITLG Proteins for Homo sapiens (Human)

KITLG ELISA Kit

KITLG ELISA Kit for Homo sapiens (Human)

KITLG ELISA Kit for Mus musculus (Mouse)

KITLG ELISA Kit for Rattus norvegicus (Rat)