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Your Good Partner in Biology Research

KIT

Kit,全稱為酪氨酸激酶受體c-Kit,是一種重要的細胞表面受體,在多種生理和病理過程中發揮關鍵作用。常見別名包括CD117和SCFR。Kit蛋白參與多種細胞功能,如細胞增殖、分化、存活和遷移,對造血細胞、肥大細胞和黑色素細胞的發育至關重要。在腫瘤發生中,Kit蛋白的突變會導致其持續激活,進而引發細胞不受控制地增殖,與胃腸道間質瘤(GIST)、黑色素瘤、急性髓細胞性白血病等多種癌癥密切相關。針對Kit蛋白的藥物研發已成為癌癥治療的重要方向。目前,已有多種Kit抑制劑被開發出來,如伊馬替尼、舒尼替尼和瑞戈非尼等,它們通過抑制Kit蛋白的活性,有效控制腫瘤細胞的生長。此外,新型藥物如瑞派替尼和avapritinib等,則針對Kit蛋白的不同突變體,展現出更高的選擇性和療效。這些藥物的研發和應用,為Kit蛋白突變相關的癌癥患者提供了新的治療選擇,顯著改善了患者的預后。

熱銷產品

Recombinant Mouse Mast/stem cell growth factor receptor Kit (Kit), partial (Active) (CSB-MP012375MO)

驗證數據

CSB-MP012375MO

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012375MO

Activity
Measured by its binding ability in a functional ELISA.Immobilized Mouse Kitlg(CSB-MP012376MO1) at 2 μg/ml can bind Mouse Kit.The EC50 is 15.57-20.95 ng/mL.

CSB-MP012375MO

The purity of Kit was greater than 90% as determined by SEC-HPLC

Recombinant Human Mast/stem cell growth factor receptor Kit (KIT), partial (Active) (CSB-MP012375HU1)

驗證數據

CSB-MP012375HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP012375HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human KIT at 2 μg/ml can bind Human KITLG (CSB-MP002061HU1i9). The EC50 is 0.6921-0.8551 ng/mL.

CSB-MP012375HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human KIT at 2 μg/ml can bind Anti-KIT recombinant antibody(CSB-RA012375MA1HU). The EC50 is 2.196-2.634 ng/mL.

KIT Recombinant Monoclonal Antibody (CSB-RA012375MA1HU)

驗證數據

CSB-RA012375MA1HU

IHC image of CSB-RA012375MA1HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA012375MA1HU

Overlay Peak curve showing JK cells stained with CSB-RA012375MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

KIT Antibody (CSB-PA07109A0Rb)

驗證數據

CSB-PA07109A0Rb

Immunofluorescent analysis of MCF-7 cells using CSB-PA07109A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human Stem Cell Factor Receptor,SCFR ELISA kit (CSB-E04721h)

驗證數據

CSB-E04721h 標準曲線

貨號:CSB-E04721h

規格:96T/48T

靈敏度:0.39 ng/mL

檢測范圍:1.56 ng/mL-100 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

KIT Antibodies

KIT for Homo sapiens (Human)

KIT Proteins

KIT Proteins for Homo sapiens (Human)

KIT Proteins for Bos taurus (Bovine)

KIT Proteins for Mus musculus (Mouse)

KIT Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

KIT Proteins for Gallus gallus (Chicken)

KIT Proteins for Felis catus (Cat) (Felis silvestris catus)

KIT Proteins for Capra hircus (Goat)

KIT Proteins for Sus scrofa (Pig)

KIT Proteins for Callithrix jacchus (White-tufted-ear marmoset)

KIT Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

KIT Proteins for Xenopus laevis (African clawed frog)

KIT ELISA Kit

KIT ELISA Kit for Homo sapiens (Human)