KCNQ1
KCNQ1，全稱為鉀電壓門控通道Q亞家族成員1，常見別名包括Jervell和Lange-Nielsen綜合征1（JLNS1）、Kv7.1等。該蛋白是心臟和神經(jīng)系統(tǒng)中重要的離子通道，參與形成緩慢激活延遲整流鉀電流，對(duì)維持心肌細(xì)胞復(fù)極化和神經(jīng)細(xì)胞功能至關(guān)重要。KCNQ1蛋白異常與多種疾病相關(guān)，如長(zhǎng)QT綜合征、Jervell和Lange-Nielsen綜合征等，這些疾病表現(xiàn)為心律失常和聽力障礙。此外，KCNQ1還與2型糖尿病發(fā)病風(fēng)險(xiǎn)相關(guān)，研究表明其基因多態(tài)性可能影響胰島素分泌功能。在藥物研發(fā)方面，針對(duì)KCNQ1通道的藥物已被用于治療心律失常和癲癇等疾病，例如某些鉀通道阻滯劑可延長(zhǎng)QT間期，而KCNQ1激活劑則被探索用于改善心臟功能。隨著對(duì)KCNQ1蛋白功能的深入研究，未來(lái)有望開發(fā)出更多針對(duì)相關(guān)疾病的精準(zhǔn)治療藥物。
熱銷產(chǎn)品
Recombinant Human Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1) (CSB-CF012087HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: HT29 cells, mouse kidney tissue, Mouse heart tissue, Primary antibody: CSB-PA237012(KCNQ1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
KCNQ1 Antibodies
KCNQ1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA237012 | KCNQ1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA942745 | KCNQ1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
KCNQ1 Proteins
KCNQ1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012087HU1 CSB-EP012087HU1 CSB-BP012087HU1 CSB-MP012087HU1 CSB-EP012087HU1-B |
Recombinant Human Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012087HU | Recombinant Human Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1) | in vitro E.coli expression system |
| CSB-MP012087HU | Recombinant Human Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1)-VLPs | Mammalian cell |
