ITGB8

ITGB8，全稱為整合素β8（Integrin subunit beta 8），是一種參與細(xì)胞外基質(zhì)相互作用的蛋白質(zhì)，常見(jiàn)別名為CD299。該蛋白與α亞基結(jié)合形成異二聚體整合素，在細(xì)胞粘附、遷移和信號(hào)傳導(dǎo)中發(fā)揮關(guān)鍵作用。ITGB8蛋白主要參與免疫應(yīng)答和炎癥反應(yīng)，通過(guò)調(diào)節(jié)細(xì)胞因子和生長(zhǎng)因子的表達(dá)影響免疫細(xì)胞的功能。此外，ITGB8蛋白還與腫瘤的發(fā)生發(fā)展密切相關(guān)，其在結(jié)直腸癌等惡性腫瘤中的高表達(dá)與腫瘤的侵襲和轉(zhuǎn)移密切相關(guān)。針對(duì)ITGB8蛋白的藥物研發(fā)已取得一定進(jìn)展，例如通過(guò)抑制ITGB8蛋白的表達(dá)或活性，可以有效抑制腫瘤細(xì)胞的生長(zhǎng)和轉(zhuǎn)移。目前，一些靶向ITGB8蛋白的小分子化合物和抗體藥物正在臨床研究中，有望成為治療腫瘤等疾病的新型藥物。

熱銷(xiāo)產(chǎn)品

ITGB8 Antibody (CSB-PA011892ESR1HU)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: ITGB8 antibody at 1.52µg/ml
Lane 1: 293T whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Lane 4: A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 86, 72 kDa
Observed band size: 86 kDa

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA011892ESR1HU at dilution of 1:100

ITGB8 Antibody

ITGB8 Protein

ITGB8 ELISA Kit

ITGB8 Antibodies

ITGB8 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA011892ESR1HU	ITGB8 Antibody	Human	ELISA, WB, IHC

ITGB8 Proteins

ITGB8 Proteins for Oryctolagus cuniculus (Rabbit)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP011892RB	Recombinant Rabbit Integrin beta-8 (ITGB8), partial	Yeast
CSB-CF011892RB	Recombinant Rabbit Integrin beta-8 (ITGB8)	in vitro E.coli expression system
CSB-EP011892RB	Recombinant Rabbit Integrin beta-8 (ITGB8), partial	E.coli
CSB-BP011892RB CSB-MP011892RB CSB-EP011892RB-B	Recombinant Rabbit Integrin beta-8 (ITGB8), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ITGB8 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP011892HU1 CSB-EP011892HU1 CSB-BP011892HU1 CSB-MP011892HU1 CSB-EP011892HU1-B	Recombinant Human Integrin beta-8 (ITGB8), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF011892HU	Recombinant Human Integrin beta-8 (ITGB8)	in vitro E.coli expression system