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Your Good Partner in Biology Research

ITGA5

整合素α5(ITGA5)是細胞表面粘附分子家族的重要成員,常與β1亞基結合形成α5β1異源二聚體受體。ITGA5因能特異性識別纖維連接蛋白中的RGD序列,被稱作纖維連接蛋白受體,在胚胎發育、創傷修復等生理過程中調控細胞粘附與遷移。α5β1通過激活細胞內FAK/Src信號網絡,促進腫瘤細胞侵襲轉移能力,其異常表達與乳腺癌、肝癌、結直腸癌等惡性腫瘤的進展密切相關。在特發性肺纖維化、動脈粥樣硬化等疾病中,ITGA5也參與異常細胞外基質沉積過程。目前針對α5β1的靶向藥物已有十余種進入臨床研究,如單抗藥物Volociximab在卵巢癌治療中顯示出抑制血管新生的潛力,小分子抑制劑JSM6427則應用于眼底黃斑病變的干預。由于整合素家族存在功能代償效應,部分藥物在臨床試驗中出現療效波動,如何精準調控其活性仍是研發難點。

熱銷產品

ITGA5 Recombinant Monoclonal Antibody (CSB-RA011868MA1HU)

驗證數據

CSB-RA011868MA1HU

IHC image of CSB-RA011868MA1HU diluted at 1:50 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

ITGA5 Antibodies

ITGA5 for Homo sapiens (Human)

ITGA5 Proteins

ITGA5 Proteins for Mus musculus (Mouse)

ITGA5 Proteins for Homo sapiens (Human)

ITGA5 Proteins for Bos taurus (Bovine)