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Your Good Partner in Biology Research

IL36RN

IL36RN,即白介素-36受體拮抗劑(Interleukin-36 receptor antagonist),也被稱為IL-1家族成員5(IL-1F5)。作為天然免疫調節因子,它通過阻斷IL-36與細胞表面受體的結合,維持皮膚、肺等組織的免疫穩態。當該蛋白功能缺失時,IL-36介導的炎癥反應會異常增強,導致中性粒細胞過度浸潤和組織損傷。
IL36RN的遺傳突變與泛發性膿皰型銀屑病(GPP)存在強關聯,超80%的家族性GPP患者攜帶其突變基因。臨床表現為突發高熱伴隨全身無菌性膿皰,嚴重時可危及生命。近年來針對這一靶點的藥物研發進展迅速,全球首個IL-36抑制劑斯佩格單抗(spesolimab)已于2022年獲FDA批準用于GPP急性發作,III期試驗顯示超半數患者在用藥一周內膿皰完全消退。目前還有多個同類生物制劑和小分子藥物處于臨床試驗階段,為炎癥性皮膚病治療開辟了新方向。

熱銷產品

Recombinant Human Interleukin-36 receptor antagonist protein (IL36RN) (CSB-EP866201HU)

驗證數據

CSB-EP866201HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

IL36RN Antibody (CSB-PA866201HA01HU)

驗證數據

CSB-PA866201HA01HU

Western blot
All lanes: IL36RN antibody at 16µg/ml + Mouse stomach tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 17 kDa
Observed band size: 17 kDa

CSB-PA866201HA01HU

Western Blot
Positive WB detected in: Rat kidney tissue
All lanes: IL36RN antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 17 kDa
Observed band size: 17 kDa

IL36RN Antibodies

IL36RN for Homo sapiens (Human)

IL36RN Proteins

IL36RN Proteins for Homo sapiens (Human)

IL36RN ELISA Kit

IL36RN ELISA Kit for Homo sapiens (Human)