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IGF2BP2

IGF2BP2,全稱為Insulin-like growth factor 2 mRNA-binding protein 2,別名IMP2或VICKZ2,是一種RNA結合蛋白,主要功能是結合胰島素樣生長因子2(IGF2)的mRNA,調節其翻譯效率。該蛋白在多種組織中表達,與細胞代謝密切相關,參與調節細胞生長、分化和代謝等過程。IGF2BP2在多種癌癥中高表達,如頭頸部鱗癌、口腔鱗狀細胞癌、喉癌、鼻咽癌和下咽癌等,與腫瘤的分期、淋巴結轉移及不良預后相關。研究表明,IGF2BP2通過結合靶mRNA(如IGF2、MYC和β-catenin等)促進其穩定性和翻譯效率,從而影響細胞生長、分化和代謝。此外,IGF2BP2還與miRNAs、lncRNAs和circRNAs等非編碼RNA相互作用,共同參與對靶mRNA的調控。目前,針對IGF2BP2的藥物研發尚處于早期階段,但已發現一些能夠干擾IGF2BP2與關鍵靶mRNA結合的小分子化合物,為癌癥治療提供了新的思路。

熱銷產品

IGF2BP2 Antibody (CSB-PA908724)

驗證數據

CSB-PA908724

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA908724(IGF2BP2 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA908724

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA908724(IGF2BP2 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA908724

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: CSB-PA908724(IGF2BP2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds

Human Insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2) ELISA kit (CSB-EL011091HU)

驗證數據

CSB-EL011091HU 標準曲線

貨號:CSB-EL011091HU

規格:96T/48T

靈敏度:31.25 pg/mL

檢測范圍:125 pg/mL-8000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

IGF2BP2 Antibodies

IGF2BP2 for Homo sapiens (Human)

IGF2BP2 Proteins

IGF2BP2 Proteins for Homo sapiens (Human)

IGF2BP2 ELISA Kit

IGF2BP2 ELISA Kit for Homo sapiens (Human)