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GZMB

GZMB,即顆粒酶B,別名CCPI、CGL-1、CSP-B、CGL1、CTSGL1、HLP、SECT。GZMB是一種由細胞毒性T細胞(CTLs)和自然殺傷細胞(NK細胞)產生的絲氨酸蛋白酶,屬于細胞毒性淋巴細胞顆粒中的酶類。GZMB的作用機制包括其在細胞外環境中的作用,如導致炎癥、血管功能障礙和通透性、細胞粘附減少、基質隔離生長因子的釋放、受體激活和細胞外基質裂解。GZMB在多種病理狀態下發揮作用,包括心血管疾病、自身免疫性疾病、腫瘤免疫逃逸等。GZMB不僅參與細胞凋亡過程,還與炎癥反應、組織重塑和腫瘤免疫監視有關。GZMB的活性受到嚴格調控,其異常表達與多種疾病的發生發展相關,是一個有潛力的治療靶點和生物標志物。

熱銷產品

Recombinant Human Granzyme B (GZMB) (CSB-EP010082HU)

驗證數據

CSB-EP010082HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GZMB Recombinant Monoclonal Antibody (CSB-RA010082MA1HU)

驗證數據

CSB-RA010082MA1HU

Western Blot Positive WB detected in:K562 whole cell lysate (20μg) All lanes: GZMB antibody at 1:1000 Secondary Goat polyclonal to mouse IgG at 1/50000 dilution Predicted band size:27.7 kDa Observed band size:28 kDa Exposure time:300s

CSB-RA010082MA1HU

IHC image of CSB-RA010082MA1HU diluted at 1:50 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA010082MA1HU

Overlay Peak curve showing THP-1 cells stained with CSB-RA010082MA1HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was mouse IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

GZMB Antibodies

GZMB for Homo sapiens (Human)

GZMB Proteins

GZMB Proteins for Homo sapiens (Human)

GZMB Proteins for Rattus norvegicus (Rat)

GZMB Proteins for Mus musculus (Mouse)

GZMB ELISA Kit

GZMB ELISA Kit for Homo sapiens (Human)

GZMB ELISA Kit for Mus musculus (Mouse)