GPR183
GPR183，即G蛋白偶聯(lián)受體183，別名包括EBI2和粘附G蛋白偶聯(lián)受體A1。該蛋白屬于G蛋白偶聯(lián)受體家族，主要在免疫細(xì)胞中表達(dá)，參與淋巴細(xì)胞、樹(shù)突狀細(xì)胞和巨噬細(xì)胞的遷移和分布。GPR183通過(guò)與氧甾醇結(jié)合，激活下游信號(hào)通路，影響免疫細(xì)胞的活化和功能。研究發(fā)現(xiàn)，GPR183的表達(dá)與多種疾病相關(guān)，包括結(jié)核病、急性髓系白血病、慢性淋巴細(xì)胞白血病等。在結(jié)核病中，GPR183表達(dá)降低與病情嚴(yán)重程度增加有關(guān)。此外，GPR183還與炎癥性腸病的發(fā)生發(fā)展密切相關(guān)，阻斷GPR183受體可能為該疾病的治療提供新的策略。目前，針對(duì)GPR183的藥物研發(fā)取得了一定進(jìn)展，例如諾華公司報(bào)道的小分子抑制劑NIBR189和南京艾美斐公司報(bào)道的GPR183小分子抑制劑在動(dòng)物模型中顯示出良好的抗炎和抗腫瘤活性。這些研究為GPR183相關(guān)疾病的治療提供了新的思路和方向。
熱銷產(chǎn)品
GPR183 Antibody (CSB-PA009792LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA009792LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA009792LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA009792LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
GPR183 Antibodies
GPR183 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009792GA01HU | GPR183 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA009792LA01HU | GPR183 Antibody | Human | ELISA, IHC, IF |
GPR183 Proteins
GPR183 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP009792HU1 CSB-EP009792HU1 CSB-BP009792HU1 CSB-MP009792HU1 CSB-EP009792HU1-B |
Recombinant Human G-protein coupled receptor 183 (GPR183), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009792HU | Recombinant Human G-protein coupled receptor 183 (GPR183) | in vitro E.coli expression system |
GPR183 Proteins for Salmo salar (Atlantic salmon)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP009792SWI1 CSB-EP009792SWI1 CSB-BP009792SWI1 CSB-MP009792SWI1 CSB-EP009792SWI1-B |
Recombinant Salmo salar G-protein coupled receptor 183 (gpr183), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009792SWI | Recombinant Salmo salar G-protein coupled receptor 183 (gpr183) | in vitro E.coli expression system |
GPR183 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP636237BO1 CSB-EP636237BO1 CSB-BP636237BO1 CSB-MP636237BO1 CSB-EP636237BO1-B |
Recombinant Bovine G-protein coupled receptor 183 (GPR183), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF636237BO | Recombinant Bovine G-protein coupled receptor 183 (GPR183) | in vitro E.coli expression system |
GPR183 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP661031MO1 CSB-EP661031MO1 CSB-BP661031MO1 CSB-MP661031MO1 CSB-EP661031MO1-B |
Recombinant Mouse G-protein coupled receptor 183 (Gpr183), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF661031MO | Recombinant Mouse G-protein coupled receptor 183 (Gpr183) | in vitro E.coli expression system |
