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GPR158

GPR158,即G蛋白偶聯(lián)受體158,別名mGlyR。這是一種在大腦中高度表達(dá)的受體,屬于孤兒G蛋白偶聯(lián)受體家族。GPR158的作用機(jī)制獨(dú)特,它通過(guò)與甘氨酸結(jié)合,激活RGS蛋白(Regulators of G protein signaling),從而抑制G蛋白信號(hào)傳導(dǎo),而不是像大多數(shù)GPCR那樣激活G蛋白。這種抑制作用是通過(guò)調(diào)節(jié)第二信使的平衡來(lái)控制神經(jīng)元活動(dòng),對(duì)大腦生理學(xué)產(chǎn)生顯著影響。GPR158的異常表達(dá)與多種疾病相關(guān),包括抑郁癥、阿爾茨海默病、青光眼和膠質(zhì)瘤等。GPR158的激活可以增強(qiáng)RGS蛋白的活性,這兩種蛋白質(zhì)共同作用以調(diào)節(jié)第二信使的體內(nèi)平衡。GPR158是抗抑郁藥開發(fā)的潛在新靶點(diǎn)。

熱銷產(chǎn)品

GPR158 Antibody (CSB-PA735975LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA735975LA01HU

IHC image of CSB-PA735975LA01HU diluted at 1:500 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA735975LA01HU

IHC image of CSB-PA735975LA01HU diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA735975LA01HU

Immunofluorescence staining of U251 cells with CSB-PA735975LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

GPR158 Antibodies

GPR158 for Homo sapiens (Human)

GPR158 Proteins

GPR158 Proteins for Homo sapiens (Human)

GPR158 Proteins for Mus musculus (Mouse)