GPNMB
跨膜糖蛋白GPNMB全稱(chēng)為黑色素瘤非轉(zhuǎn)移性糖蛋白B，常被稱(chēng)為骨激活素或樹(shù)突狀細(xì)胞相關(guān)跨膜蛋白。GPNMB廣泛分布于黑色素細(xì)胞、破骨細(xì)胞及免疫細(xì)胞表面，主要參與細(xì)胞間識(shí)別與微環(huán)境調(diào)控，其異常表達(dá)常伴隨腫瘤侵襲性增強(qiáng)和免疫逃逸現(xiàn)象。GPNMB在超過(guò)40%的三陰性乳腺癌和惡性黑色素瘤中過(guò)度活躍，其介導(dǎo)的促存活信號(hào)可能加速腫瘤轉(zhuǎn)移。在神經(jīng)退行性疾病領(lǐng)域，該蛋白與β淀粉樣蛋白存在相互作用，可能影響阿爾茨海默病的病理進(jìn)程。目前全球有多款靶向GPNMB的藥物進(jìn)入臨床階段，其中抗體偶聯(lián)藥物CDX-011在轉(zhuǎn)移性乳腺癌的Ⅱ期試驗(yàn)中顯示出可控安全性，新型雙抗藥物GT-002則通過(guò)阻斷GPNMB與整合素結(jié)合來(lái)抑制骨肉瘤生長(zhǎng)。某些小分子抑制劑已證實(shí)可穿透血腦屏障，為神經(jīng)相關(guān)疾病的治療開(kāi)辟了新方向。
熱銷(xiāo)產(chǎn)品
GPNMB Recombinant Monoclonal Antibody (CSB-RA622928MA1HU)
驗(yàn)證數(shù)據(jù)
Overlay Peak curve showing Hela cells stained with CSB-RA622928MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 003 events was performed.
Human Transmembrane glycoprotein NMB(GPNMB) ELISA kit (CSB-EL009727HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL009727HU
規(guī)格：96T/48T
靈敏度：0.195 ng/mL
檢測(cè)范圍：0.78 ng/mL-50 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
GPNMB Antibodies
GPNMB for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA009727GA01HU | GPNMB Antibody | Human,Mouse | ELISA,IHC |
| CSB-RA622928MA1HU | GPNMB Recombinant Monoclonal Antibody | Human | ELISA, FC |
GPNMB Proteins
GPNMB Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP622928HU CSB-EP622928HU CSB-BP622928HU CSB-MP622928HU CSB-EP622928HU-B |
Recombinant Human Transmembrane glycoprotein NMB (GPNMB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GPNMB Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP740736RA CSB-EP740736RA CSB-BP740736RA CSB-MP740736RA CSB-EP740736RA-B |
Recombinant Rat Transmembrane glycoprotein NMB (Gpnmb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GPNMB Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP860839MO CSB-EP860839MO CSB-BP860839MO CSB-MP860839MO CSB-EP860839MO-B |
Recombinant Mouse Transmembrane glycoprotein NMB (Gpnmb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GPNMB ELISA Kit
GPNMB ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-EL009727HU | Human Transmembrane glycoprotein NMB(GPNMB) ELISA kit | serum, plasma, tissue homogenates | 0.195 ng/mL |
| CSB-EL009727HU-IS | Human Transmembrane glycoprotein NMB(GPNMB) ELISA kit | serum, plasma, tissue homogenates, cell culture supernates | 0.039 ng/mL |
GPNMB ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-EL009727MO | Mouse Transmembrane glycoprotein NMB(GPNMB) ELISA kit | serum, plasma, tissue homogenates | 0.195ng/ml |
