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G3BP1

G3BP1,全稱Ras-GTPase-activating protein SH3 domain-binding protein 1,別名G3BP、HDH-VIII,是一種在細(xì)胞應(yīng)激反應(yīng)中發(fā)揮重要作用的蛋白質(zhì)。它參與應(yīng)激顆粒的組裝,并能夠調(diào)節(jié)細(xì)胞的鐵死亡過(guò)程。G3BP1在多種惡性腫瘤組織中表達(dá)上調(diào),例如乳腺癌、結(jié)腸癌、頭頸部癌等,其高表達(dá)與腫瘤細(xì)胞的增殖、侵襲和轉(zhuǎn)移密切相關(guān)。此外,G3BP1還在宮頸癌、膀胱癌等腫瘤的發(fā)生發(fā)展中發(fā)揮重要作用,并可能成為腫瘤治療的潛在靶點(diǎn)。目前,針對(duì)G3BP1的藥物研發(fā)正在積極開(kāi)展,例如設(shè)計(jì)合成靶向G3BP1的PROTAC分子,以降解G3BP1蛋白,從而抑制腫瘤細(xì)胞的生長(zhǎng)和轉(zhuǎn)移。此外,G3BP1也被發(fā)現(xiàn)與溶酶體自噬活性相關(guān),參與調(diào)節(jié)細(xì)胞的鐵死亡過(guò)程,為治療椎間盤(pán)退變等疾病提供了新的思路。

熱銷產(chǎn)品

Recombinant Human Ras GTPase-activating protein-binding protein 1 (G3BP1) (CSB-EP613389HU(A4)a0)

驗(yàn)證數(shù)據(jù)

CSB-EP613389HU(A4)a0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

G3BP1 Recombinant Monoclonal Antibody (CSB-RA583845A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA583845A0HU

Western Blot
Positive WB detected in: Hela whole cell lysate(30μg), JURKAT whole cell lysate(30μg), K562 whole cell lysate(30μg), NIH/3T3 whole cell lysate(30μg)
All lanes: G3BP1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 52 kDa
Observed band size: 70 kDa
Exposure time:1min

CSB-RA583845A0HU

IHC image of CSB-RA583845A0HU diluted at 1:100 and staining in paraffin-embedded human colorectal cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA583845A0HU

Immunofluorescence staining of HepG2 cell with CSB-RA583845A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA583845A0HU

Overlay Peak curve showing Hela cells stained with CSB-RA583845A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

G3BP1 Antibodies

G3BP1 for Homo sapiens (Human)

G3BP1 Proteins

G3BP1 Proteins for Mus musculus (Mouse)

G3BP1 Proteins for Homo sapiens (Human)

G3BP1 Proteins for Bos taurus (Bovine)

G3BP1 Proteins for Pongo abelii (Sumatran orangutan)