日韩在线视频不卡-日一区二区三区-天堂国产+人+综合+亚洲欧美-精品国产一区二区三区久久狼-国产成人无码18禁午夜福利网址-国产在线拍偷自揄拍精品-九色91丨porny丨丝袜-久久天天躁狠狠躁夜夜av-99蜜桃臀久久久欧美精品-成人一区二区视频-狠狠操人人干-40岁干柴烈火少妇高潮不断-国产福利不卡-伊人98-丰满多毛的陰户视频-日韩一二三四五区-国产专区一线二线三线码-好男人社区影院www-国产精品2019-欧美三级一区

Your Good Partner in Biology Research

FOXA1

FOXA1,即叉頭框蛋白A1,別名HNF3α。FOXA1是一種在多個生物學過程中起核心作用的轉錄因子,包括器官發生、分化、糖脂代謝、細胞增殖、遷移和侵襲,以及藥物抗性。FOXA1通過結合到基因組上的特定區域,幫助打開染色質結構,從而作為先鋒因子促進其他轉錄因子的結合和基因的轉錄。在癌癥中,FOXA1與激素受體如雌激素受體ER和雄激素受體AR等相互作用,調控相關癌癥的發生、發展、轉移、耐藥等過程。FOXA1的突變或表觀遺傳修飾與多種癌癥的發展和治療抗性相關,尤其是在雌激素受體陽性的乳腺癌和前列腺癌中。FOXA1還參與調節多種代謝途徑,包括糖代謝和脂代謝,影響細胞的代謝狀態和能量平衡。因此,FOXA1在維持細胞正常功能和促進疾病進展中扮演著關鍵角色,是癌癥治療中的一個重要靶點。

熱銷產品

Recombinant Human Hepatocyte nuclear factor 3-alpha (FOXA1) (CSB-EP008794HU)

驗證數據

CSB-EP008794HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FOXA1 Recombinant Monoclonal Antibody (CSB-RA246102A0HU)

驗證數據

CSB-RA246102A0HU

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, HepG2 whole cell lysate, PC-3 whole cell lysate, 293 whole cell lysate, Hela whole cell lysate
All lanes: FOXA1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 50, 46 kDa
Observed band size: 50 kDa

CSB-RA246102A0HU

IHC image of CSB-RA246102A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA246102A0HU

IHC image of CSB-RA246102A0HU diluted at 1:100 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA246102A0HU

Immunoprecipitating FOXA1 in Hela whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-RA246102A0HU in Hela whole cell lysate. For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-RA246102A0HU(2μg)+ Hela whole cell lysate(500μg)
Lane 3: Hela whole cell lysate (10μg)

FOXA1 Antibodies

FOXA1 for Homo sapiens (Human)

FOXA1 Proteins

FOXA1 Proteins for Mus musculus (Mouse)

FOXA1 Proteins for Rattus norvegicus (Rat)

FOXA1 Proteins for Homo sapiens (Human)

FOXA1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)