FGFR2
FGFR2，即成纖維細胞生長因子受體2，別名FGFRβ、Bek、CFD1等。FGFR2是一種跨膜受體酪氨酸激酶，由人體細胞自身的基因編碼，主要在胚胎發(fā)育、組織再生、細胞增殖和遷移等過程中發(fā)揮作用。FGFR2的作用機制涉及與多種成纖維細胞生長因子(FGF)配體結(jié)合，如FGF1、FGF2、FGF4、FGF5等，進而激活其內(nèi)在的酪氨酸激酶活性，啟動下游的信號傳導途徑，如RAS/RAF/MEK/ERK、PI3K/AKT等。FGFR2在生物學上的意義非常廣泛，它參與調(diào)節(jié)多種細胞過程，包括細胞增殖、分化、遷移和存活。FGFR2的信號通路與組織發(fā)育、傷口愈合、腫瘤生長和血管生成等生理和病理過程密切相關。FGFR2的功能異常與多種疾病有關，尤其是與某些類型的癌癥相關，如乳腺癌、胃癌、非小細胞肺癌等。在腫瘤中，F(xiàn)GFR2的突變或過表達可能導致細胞增殖失控和腫瘤血管生成，促進腫瘤的侵襲和轉(zhuǎn)移。因此，F(xiàn)GFR2是腫瘤治療中的一個潛在靶點，針對FGFR2的抑制劑正在被開發(fā)用于治療相關癌癥。
熱銷產(chǎn)品
驗證數(shù)據(jù)
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
-AC1.jpg)
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human FGFR2 at 2 μg/ml can bind Anti-FGFR2 recombinant antibody (CSB-RA008645MA1HU). The EC50 is 1.066-1.203 ng/mL.
驗證數(shù)據(jù)
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
-AC1.jpg)
Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse FGFR2 at 2 μg/ml can bind Anti-FGFR2 recombinant antibody (CSB-RA008645MA1HU). The EC50 is 2.084-2.249 ng/mL.
Recombinant Human Fibroblast growth factor receptor 2 (FGFR2), partial (Active) (CSB-MP008645HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human FGFR2 at 2 μg/ml can bind Anti-FGFR2 recombinant antibody (CSB-RA008645MA2HU). The EC50 is 2.051-2.322 ng/mL.
Recombinant Human Fibroblast growth factor receptor 2 (FGFR2), partial (Active) (CSB-MP008645HU(F3))
驗證數(shù)據(jù)
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
-AC1.jpg)
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human FGFR2 at 2 μg/ml can bind Anti-FGFR2 recombinant antibody (CSB-RA008645MA1HU). The EC50 is 1.066-1.203 ng/mL.
-HPLC.jpg)
The purity of FGFR2 was greater than 95% as determined by SEC-HPLC
FGFR2 Recombinant Monoclonal Antibody (CSB-RA154582A0HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: Rat Brain whole cell lysate, Rat Lung whole cell lysate, Mouse Brain whole cell lysate
All lanes: FGFR2 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 93, 87, 93, 77, 92, 89, 86, 29, 80, 93, 97, 92, 41, 80, 80, 77, 80 kDa
Observed band size: 145 kDa
FGFR2 Antibodies
FGFR2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA008645GA01HU | FGFR2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA077444 | FGFR2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA000992 | FGFR2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA449267 | FGFR2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA151107 | FGFR2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA008645LA01HU | FGFR2 Antibody | Human | ELISA, IHC |
| CSB-PA008645LB01HU | FGFR2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008645LC01HU | FGFR2 Antibody, FITC conjugated | Human | |
| CSB-RA154582A0HU | FGFR2 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB |
| CSB-RA008645MA1HU | FGFR2 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
FGFR2 Proteins
FGFR2 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008645CH1 CSB-EP008645CH1 CSB-BP008645CH1 CSB-MP008645CH1 CSB-EP008645CH1-B |
Recombinant Chicken Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008645CH | Recombinant Chicken Fibroblast growth factor receptor 2 (FGFR2) | in vitro E.coli expression system |
FGFR2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008645HU1 CSB-EP008645HU1 CSB-BP008645HU1 CSB-EP008645HU1-B |
Recombinant Human Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF008645HU | Recombinant Human Fibroblast growth factor receptor 2 (FGFR2) | in vitro E.coli expression system |
FGFR2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008645MO1 CSB-EP008645MO1 CSB-BP008645MO1 CSB-MP008645MO1 CSB-EP008645MO1-B |
Recombinant Mouse Fibroblast growth factor receptor 2 (Fgfr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008645MO | Recombinant Mouse Fibroblast growth factor receptor 2 (Fgfr2) | in vitro E.coli expression system |
FGFR2 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008645XBE1 CSB-EP008645XBE1 CSB-BP008645XBE1 CSB-MP008645XBE1 CSB-EP008645XBE1-B |
Recombinant Xenopus laevis Fibroblast growth factor receptor 2 (fgfr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008645XBE | Recombinant Xenopus laevis Fibroblast growth factor receptor 2 (fgfr2) | in vitro E.coli expression system |
FGFR2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008645DIL CSB-EP008645DIL CSB-BP008645DIL CSB-MP008645DIL CSB-EP008645DIL-B |
Recombinant Danio rerio Fibroblast growth factor receptor 2 (fgfr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR2 Proteins for Pleurodeles waltl (Iberian ribbed newt)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008645EWZ CSB-EP008645EWZ CSB-BP008645EWZ CSB-MP008645EWZ CSB-EP008645EWZ-B |
Recombinant Pleurodeles waltl Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR2 Proteins for Dugesia japonica (Planarian)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008645DMU CSB-EP008645DMU CSB-BP008645DMU CSB-MP008645DMU CSB-EP008645DMU-B |
Recombinant Dugesia japonica Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FGFR2 Proteins for Notophthalmus viridescens (Eastern newt) (Triturus viridescens)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008645NEO CSB-EP008645NEO CSB-BP008645NEO CSB-MP008645NEO CSB-EP008645NEO-B |
Recombinant Notophthalmus viridescens Fibroblast growth factor receptor 2 (FGFR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
