E7蛋白具有轉(zhuǎn)化活性和反式激活活性。 結(jié)構(gòu)為兩個(gè)功能區(qū)域：一個(gè)是N末端區(qū)域，含有保守的Cys-X-X-Cys（CXXC）結(jié)構(gòu)，用于與細(xì)胞中的特定蛋白質(zhì)相互作用；另一個(gè)是C末端區(qū)域，包含保守的LXCXE序列，用于與細(xì)胞中的Rb蛋白（Retinoblastoma protein）結(jié)合。E7蛋白通過(guò)與細(xì)胞中的Rb蛋白結(jié)合，抑制Rb蛋白的功能，導(dǎo)致細(xì)胞周期的失控和異常增殖。這會(huì)使細(xì)胞失去正常的生長(zhǎng)抑制機(jī)制，促進(jìn)細(xì)胞轉(zhuǎn)變和癌變。E7靶點(diǎn)及其與Rb蛋白相互作用的研究已成為HPV相關(guān)癌癥治療和疫苗研發(fā)的重要方向，是HPV感染中的關(guān)鍵蛋白之一，它與細(xì)胞周期調(diào)控、轉(zhuǎn)錄調(diào)控和細(xì)胞增殖等過(guò)程密切相關(guān)。

熱銷產(chǎn)品

● Recombinant Human papillomavirus type 16 Protein E7 (E7)

驗(yàn)證數(shù)據(jù)

SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LC-MS/MS

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP365855HML could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) E7.

LC-MS/MS

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP365855HML could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) E7.

● Recombinant Human papillomavirus type 18 Protein E7 (E7)

驗(yàn)證數(shù)據(jù)

SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.