DLL4
DLL4，全稱(chēng)為Delta-like protein 4，也被稱(chēng)為δ樣蛋白-4，在血管生成與重塑中發(fā)揮著核心作用。DLL4的異常表達(dá)與多種病理狀態(tài)下的血管異常生成密切相關(guān)，如腫瘤、視網(wǎng)膜病變及心血管疾病等。研究表明，DLL4不僅是血管生成的重要調(diào)控因子，其異常調(diào)控還可能通過(guò)影響內(nèi)皮細(xì)胞行為參與疾病進(jìn)展，因此成為近年來(lái)疾病治療的研究熱點(diǎn)。
DLL4的高表達(dá)與多種腫瘤如結(jié)直腸癌、肺癌、肝癌等密切相關(guān)，通過(guò)激活Notch信號(hào)通路，DLL4能夠抑制正常的血管生成，形成異常的血管網(wǎng)絡(luò)，為腫瘤的生長(zhǎng)和轉(zhuǎn)移提供有利條件。DLL4還與視網(wǎng)膜病變、心血管疾病、慢性腎病、肌肉萎縮與代謝性疾病、遺傳性血管疾病等多種疾病相關(guān)。
目前，抗DLL4抗體可抑制腫瘤血管生成，但長(zhǎng)期使用可能誘發(fā)肝血管肉瘤等毒性，因此，研究人員正在探索DLL4與其他藥物的聯(lián)合應(yīng)用，以增強(qiáng)抗腫瘤效果并降低耐藥風(fēng)險(xiǎn)。目前已有2條DLL4 x VEGF雙抗管線(xiàn)在研，最高研究階段處于臨床2/3期，為腫瘤治療提供了新的希望。
熱銷(xiāo)產(chǎn)品
Recombinant Human Delta-like protein 4 (DLL4), partial (Active) (CSB-MP878862HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human DLL4 at 2 μg/ml can bind Anti-DLL4 recombinant antibody (CSB-RA878862MA1HU). The EC50 is 2.322-2.607 ng/mL.
DLL4 (Navicixizumab) Recombinant Monoclonal Antibody (CSB-RA878862MA1HU)
驗(yàn)證數(shù)據(jù)
The Binding Activity of Human DLL4 with Anti-DLL4 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DLL4 (CSB-MP878862HU) at 2 μg/mL can bind Anti-DLL4 recombinant antibody . The EC50 is 2.322-2.607 ng/mL.
DLL4 Antibody (CSB-PA006949LA01HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescent analysis of MCF-7 cells using CSB-PA006949LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Delta-like protein 4(DLL4) ELISA kit (CSB-EL006949HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL006949HU
規(guī)格：96T/48T
靈敏度：5.8 pg/mL
檢測(cè)范圍：23.5 pg/mL-1500 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
DLL4 Antibodies
DLL4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA073786 | DLL4 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA831848 | DLL4 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA006949LA01HU | DLL4 Antibody | Human | ELISA, IF |
| CSB-PA006949LB01HU | DLL4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA006949LC01HU | DLL4 Antibody, FITC conjugated | Human | |
| CSB-PA006949LD01HU | DLL4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA878862MA1HU | DLL4 (Navicixizumab) Recombinant Monoclonal Antibody | Human | ELISA |
DLL4 Proteins
DLL4 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP347231XBE CSB-EP347231XBE CSB-BP347231XBE CSB-MP347231XBE CSB-EP347231XBE-B |
Recombinant Xenopus laevis Homeobox protein DLL-4 (dll4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DLL4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP867483MO CSB-EP867483MO CSB-BP867483MO CSB-MP867483MO CSB-EP867483MO-B |
Recombinant Mouse Delta-like protein 4 (Dll4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DLL4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP878862HU CSB-EP878862HU CSB-BP878862HU CSB-EP878862HU-B |
Recombinant Human Delta-like protein 4 (DLL4), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP878862HU | Recombinant Human Delta-like protein 4 (DLL4), partial (Active) | Mammalian cell |
DLL4 ELISA Kit
DLL4 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006949HU | Human Delta-like protein 4(DLL4) ELISA kit | serum, plasma, tissue homogenates | 5.8 pg/mL |
DLL4 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006949MO | Mouse Delta-like protein 4(DLL4) ELISA kit | serum, plasma, tissue homogenates | 0.04ng/ml |
