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DCLK1

DCLK1,即雙皮質素樣激酶1,別名CL1、DCLK、CLICK1、DCDC3A、DCAMKL1,由人類DCLK1基因編碼,該基因位于13號染色體的q13.3區域。
DCLK1是一種多結構域蛋白,屬于蛋白激酶超家族和雙皮質素家族,在神經元遷移、逆行運輸、神經元凋亡和神經發生等不同的細胞過程中發揮作用。DCLK1與記憶和一般認知能力相關,受腦源性神經營養因子上調。
DCLK1的表達異常與多種疾病相關,包括BandHeterotopia、ZellwegerSyndrome、結腸良性腫瘤、淋巴管瘤和先天性神經系統異常。DCLK1在多種人類癌癥中表達水平增加,可能通過調節NOTCH和WNT等發育途徑來影響細胞生長。

熱銷產品

DCLK1 Antibody (CSB-PA006548LA01HU)

驗證數據

CSB-PA006548LA01HU

Immunohistochemistry of paraffin-embedded human glioma using CSB-PA006548LA01HU at dilution of 1:100

CSB-PA006548LA01HU

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA006548LA01HU at dilution of 1:100

CSB-PA006548LA01HU

Immunofluorescence staining of MCF-7 cells with CSB-PA006548LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

DCLK1 Antibodies

DCLK1 for Homo sapiens (Human)

DCLK1 Proteins

DCLK1 Proteins for Rattus norvegicus (Rat)

DCLK1 Proteins for Homo sapiens (Human)

DCLK1 Proteins for Mus musculus (Mouse)