CXCR2
CXCR2全稱為C-X-C趨化因子受體2型，又稱IL-8受體β或CD182，屬于G蛋白偶聯(lián)受體超家族成員。CXCR2通過(guò)與IL-8、GROα等趨化因子結(jié)合，介導(dǎo)中性粒細(xì)胞向炎癥部位遷移，在急慢性炎癥反應(yīng)、組織修復(fù)及腫瘤微環(huán)境調(diào)控中發(fā)揮關(guān)鍵作用。CXCR2異常活化與慢性阻塞性肺病、銀屑病、類風(fēng)濕性關(guān)節(jié)炎等炎癥性疾病密切相關(guān)，其在多種實(shí)體瘤中通過(guò)招募髓系抑制細(xì)胞促進(jìn)免疫逃逸的特性也備受關(guān)注。
針對(duì)CXCR2的藥物開(kāi)發(fā)聚焦于小分子拮抗劑，如Navarixin（MK-7123）已完成銀屑病二期臨床試驗(yàn)，AZD5069在慢阻肺治療中顯示出抑制中性粒細(xì)胞浸潤(rùn)的效果。由于CXCR2拮抗可能影響正常免疫功能，部分藥物因療效不足或毒副作用終止研發(fā)。目前研究轉(zhuǎn)向聯(lián)合用藥策略，如在胰腺癌治療中與免疫檢查點(diǎn)抑制劑聯(lián)用，或開(kāi)發(fā)雙重CXCR1/CXCR2抑制劑以增強(qiáng)抗炎效果。該靶點(diǎn)的組織特異性調(diào)控機(jī)制仍是轉(zhuǎn)化醫(yī)學(xué)研究的難點(diǎn)。
熱銷產(chǎn)品
Recombinant Human C-X-C chemokine receptor type 2 (CXCR2)-VLPs (Active) (CSB-MP011673HU(A4))
驗(yàn)證數(shù)據(jù)
-WB.jpg)
CSB-MP011673HU(A4) is detected by Mouse anti-6*His monoclonal antibody.
-AC1.jpg)
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CXCR2 at 2 μg/ml can bind Anti-CXCR2 recombinant antibody (CSB-RA011673MA1HU). The EC50 is 0.3741-0.4671 ng/mL.
The VLPs (CSB-MP3838) is negative control.
Recombinant Human C-X-C chemokine receptor type 2 (CXCR2), partial (CSB-EP011673HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CXCR2 Antibody (CSB-PA011673HA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA011673HA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA011673HA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA011673HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CXCR2 Antibodies
CXCR2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011673GA01HU | CXCR2 Antibody | Human | ELISA,WB,IF |
| CSB-PA974167 | Phospho-CXCR2 (Ser347) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA005633 | CXCR2 Antibody | Human | WB, ELISA |
| CSB-PA009566 | Phospho-CXCR2 (S347) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA009567 | CXCR2 Antibody | Human,Mouse | IF, ELISA |
| CSB-PA730026 | CXCR2 Antibody | Human | ELISA,WB |
| CSB-PA282080 | CXCR2 Antibody | Human | ELISA,WB |
| CSB-PA011673HA01HU | CXCR2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA011673HB01HU | CXCR2 Antibody, HRP conjugated | Human | ELISA |
CXCR2 Proteins
CXCR2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011673HU CSB-BP011673HU CSB-MP011673HU CSB-EP011673HU-B |
Recombinant Human C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011673HU | Recombinant Human C-X-C chemokine receptor type 2 (CXCR2), partial | E.coli |
| CSB-CF011673HU(A4) | Recombinant Human C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CXCR2 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011673RB1 CSB-EP011673RB1 CSB-BP011673RB1 CSB-MP011673RB1 CSB-EP011673RB1-B |
Recombinant Rabbit C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011673RB | Recombinant Rabbit C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CXCR2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011673RA1 CSB-EP011673RA1 CSB-BP011673RA1 CSB-MP011673RA1 CSB-EP011673RA1-B |
Recombinant Rat C-X-C chemokine receptor type 2 (Cxcr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011673RA | Recombinant Rat C-X-C chemokine receptor type 2 (Cxcr2) | in vitro E.coli expression system |
CXCR2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011673MO1 CSB-EP011673MO1 CSB-BP011673MO1 CSB-MP011673MO1 CSB-EP011673MO1-B |
Recombinant Mouse C-X-C chemokine receptor type 2 (Cxcr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011673MO | Recombinant Mouse C-X-C chemokine receptor type 2 (Cxcr2) | in vitro E.coli expression system |
| CSB-MP011673MO | Recombinant Mouse C-X-C chemokine receptor type 2 (Cxcr2)-VLPs | Mammalian cell |
CXCR2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011673DO1 CSB-EP011673DO1 CSB-BP011673DO1 CSB-MP011673DO1 CSB-EP011673DO1-B |
Recombinant Dog C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011673DO | Recombinant Dog C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CXCR2 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP630684MOW1 CSB-EP630684MOW1 CSB-BP630684MOW1 CSB-MP630684MOW1 CSB-EP630684MOW1-B |
Recombinant Macaca mulatta C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF630684MOW | Recombinant Macaca mulatta C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CXCR2 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP631729EQV1 CSB-EP631729EQV1 CSB-BP631729EQV1 CSB-MP631729EQV1 CSB-EP631729EQV1-B |
Recombinant Pan troglodytes C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF631729EQV | Recombinant Pan troglodytes C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CXCR2 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP632950BO1 CSB-EP632950BO1 CSB-BP632950BO1 CSB-MP632950BO1 CSB-EP632950BO1-B |
Recombinant Bovine C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF632950BO | Recombinant Bovine C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CXCR2 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP636722GGZ1 CSB-EP636722GGZ1 CSB-BP636722GGZ1 CSB-MP636722GGZ1 CSB-EP636722GGZ1-B |
Recombinant Gorilla gorilla gorilla C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF636722GGZ | Recombinant Gorilla gorilla gorilla C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
