CX3CR1
CX3CR1全稱為CX3C趨化因子受體1，也被稱為Fractalkine受體或G蛋白偶聯(lián)受體13。這種蛋白主要分布在單核細胞、小膠質細胞和自然殺傷細胞表面，通過與其配體Fractalkine的相互作用，調控免疫細胞的遷移與黏附功能，尤其在炎癥反應和免疫監(jiān)視中發(fā)揮重要作用。研究發(fā)現(xiàn)，CX3CR1介導的細胞間通訊與神經退行性疾病密切相關，例如阿爾茨海默病患者腦內小膠質細胞的異常激活便與其功能失調存在關聯(lián)。此外，該受體在動脈粥樣硬化斑塊形成過程中參與單核細胞的浸潤，與心血管疾病的發(fā)展密切相關。
近年來，針對CX3CR1的藥物開發(fā)聚焦于炎癥性疾病治療領域。部分小分子抑制劑已在動物模型中展現(xiàn)出抑制神經炎癥和延緩動脈斑塊進展的效果。臨床前研究還發(fā)現(xiàn)，阻斷CX3CR1可能緩解類風濕性關節(jié)炎的關節(jié)損傷。目前已有單克隆抗體類藥物進入早期臨床試驗階段，嘗試通過調控免疫細胞遷移來治療多發(fā)性硬化等自身免疫疾病。與此同時，該受體在腫瘤微環(huán)境中的雙重作用也引起關注，既有研究支持其促進腫瘤免疫逃逸，也有證據(jù)表明可能增強抗腫瘤免疫應答，這一矛盾特性為靶向治療帶來挑戰(zhàn)。
熱銷產品
CX3CR1 Antibody (CSB-PA006236LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA006236LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA006236LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human CX3C-chemokine receptor 1,CX3CR1 ELISA Kit (CSB-E09942h)
驗證數(shù)據(jù)
貨號：CSB-E09942h
規(guī)格：96T/48T
靈敏度：7.8 pg/mL
檢測范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CX3CR1 Antibodies
CX3CR1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006236GA01HU | CX3CR1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA004776 | CX3CR1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA007487 | CX3CR1 Antibody | Human | IHC, IF, ELISA |
| CSB-PA135132 | CX3CR1 Antibody | Human | ELISA,WB |
| CSB-PA080771 | CX3CR1 Antibody | Human | ELISA,WB |
| CSB-PA006236LA01HU | CX3CR1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA006236LB01HU | CX3CR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA006236LC01HU | CX3CR1 Antibody, FITC conjugated | Human | |
| CSB-PA006236LD01HU | CX3CR1 Antibody, Biotin conjugated | Human | ELISA |
CX3CR1 Proteins
CX3CR1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006236HU1 CSB-EP006236HU1 CSB-BP006236HU1 CSB-MP006236HU1 CSB-EP006236HU1-B |
Recombinant Human CX3C chemokine receptor 1 (CX3CR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006236HU | Recombinant Human CX3C chemokine receptor 1 (CX3CR1) | in vitro E.coli expression system |
| CSB-MP006236HU | Recombinant Human CX3C chemokine receptor 1 (CX3CR1)-VLPs | Mammalian cell |
CX3CR1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006236BO1 CSB-EP006236BO1 CSB-BP006236BO1 CSB-MP006236BO1 CSB-EP006236BO1-B |
Recombinant Bovine CX3C chemokine receptor 1 (CX3CR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006236BO | Recombinant Bovine CX3C chemokine receptor 1 (CX3CR1) | in vitro E.coli expression system |
CX3CR1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006236RA1 CSB-EP006236RA1 CSB-BP006236RA1 CSB-MP006236RA1 CSB-EP006236RA1-B |
Recombinant Rat CX3C chemokine receptor 1 (Cx3cr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006236RA | Recombinant Rat CX3C chemokine receptor 1 (Cx3cr1) | in vitro E.coli expression system |
CX3CR1 Proteins for Oryctolagus cuniculus (Rabbit)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP644447RB1 CSB-EP644447RB1 CSB-BP644447RB1 CSB-MP644447RB1 CSB-EP644447RB1-B |
Recombinant Rabbit CX3C chemokine receptor 1 (CX3CR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF644447RB | Recombinant Rabbit CX3C chemokine receptor 1 (CX3CR1) | in vitro E.coli expression system |
CX3CR1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP897445MO1 CSB-EP897445MO1 CSB-BP897445MO1 CSB-MP897445MO1 CSB-EP897445MO1-B |
Recombinant Mouse CX3C chemokine receptor 1 (Cx3cr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF897445MO | Recombinant Mouse CX3C chemokine receptor 1 (Cx3cr1) | in vitro E.coli expression system |
CX3CR1 ELISA Kit
CX3CR1 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09942h | Human CX3C-chemokine receptor 1,CX3CR1 ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
CX3CR1 ELISA Kit for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006236RA | Rat CX3C chemokine receptor 1(CX3CR1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 5.8 pg/mL |
