CLDN1
CLDN1，全稱Claudin-1，是一種重要的緊密連接蛋白，在維持細(xì)胞間屏障功能方面發(fā)揮著關(guān)鍵作用。它主要參與形成細(xì)胞間的緊密連接結(jié)構(gòu)，調(diào)節(jié)細(xì)胞旁通透性，以及維持上皮細(xì)胞和內(nèi)皮細(xì)胞層的細(xì)胞間黏附。CLDN1在多種組織中表達(dá)，包括皮膚、肺、胃、腎臟等。其異常表達(dá)與多種疾病的發(fā)生發(fā)展相關(guān)，如魚鱗病、白細(xì)胞空泡、脫發(fā)、硬化性膽管炎綜合征、頭頸鱗狀細(xì)胞癌、肝細(xì)胞癌、結(jié)直腸癌、胃癌、卵巢癌、胰腺癌和甲狀腺癌等。目前，針對CLDN1的藥物研發(fā)取得了一定的進(jìn)展，例如Alentis Therapeutics開發(fā)的靶向CLDN1的單抗ALE.C04，以及雙特異性抗體ASP1002等，均處于臨床試驗(yàn)階段，顯示出在腫瘤治療和器官纖維化疾病治療方面的潛力。
熱銷產(chǎn)品
Recombinant Human Claudin-1 (CLDN1)-VLPs (Active) (CSB-MP005490HU)
驗(yàn)證數(shù)據(jù)
CSB-MP005490HU is detected by Mouse anti-6*His monoclonal antibody.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN1 at 10 μg/ml can bind Anti-CLDN1 recombinant antibody (CSB-RA005490MA1HU). The EC50 is 35.03-50.71 ng/mL.
The VLPs (CSB-MP3838) is negative control.
The purity of VLPs was greater than 95% as determined by SEC-HPLC
Recombinant Human Claudin-1 (CLDN1)-Detergent (Active) (CSB-MP005490HU1-D)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN1 at 2 μg/ml on an Nickel Coated plate can bind Anti-CLDN1 recombinant antibody (CSB-RA005490MA1HU). The EC50 is 62.47-72.10 ng/mL.
Recombinant Human Claudin-1 (CLDN1) (CSB-CF005490HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CLDN1 Antibody (CSB-PA005490LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA005490LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA005490LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Claudin-1(CLDN1) ELISA kit (CSB-EL005490HU)
驗(yàn)證數(shù)據(jù)
貨號：CSB-EL005490HU
規(guī)格：96T/48T
靈敏度：3.9 pg/mL
檢測范圍：15.6 pg/mL-1000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CLDN1 Antibodies
CLDN1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005490GA01HU | CLDN1 Antibody | Human,Mouse,Rat | ELISA |
| CSB-PA781428 | CLDN1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA133727 | CLDN1 (Ab-210) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA442054 | CLDN1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA001656 | CLDN1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA070223 | CLDN1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA983237 | CLDN1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA909627 | CLDN1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA005490LA01HU | CLDN1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA005490LC01HU | CLDN1 Antibody, FITC conjugated | Human | |
| CSB-PA005490LD01HU | CLDN1 Antibody, Biotin conjugated | Human | ELISA |
CLDN1 Proteins
CLDN1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP005490HU1 CSB-EP005490HU1 CSB-BP005490HU1 CSB-MP005490HU1 CSB-EP005490HU1-B |
Recombinant Human Claudin-1 (CLDN1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005490HU | Recombinant Human Claudin-1 (CLDN1) | in vitro E.coli expression system |
| CSB-MP005490HU | Recombinant Human Claudin-1 (CLDN1)-VLPs (Active) | Mammalian cell |
| CSB-CF005490HUd7 | Recombinant Human Claudin-1 (CLDN1) | in vitro E.coli expression system |
CLDN1 ELISA Kit
CLDN1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL005490HU | Human Claudin-1(CLDN1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
