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CHRM3

CHRM3,即膽堿能受體毒蕈堿3,別名 AChR、EGBRS。它是一種G蛋白偶聯(lián)受體,由CHRM3基因編碼,在多種組織中表達(dá),尤其在平滑肌、心臟和分泌腺中。CHRM3的作用機(jī)制是通過與乙酰膽堿結(jié)合,激活Gq/11蛋白,進(jìn)而促進(jìn)磷脂酰肌醇4,5-二磷酸(PIP2)轉(zhuǎn)化為肌醇三磷酸(IP3)和二酰甘油(DAG),引起細(xì)胞內(nèi)鈣離子釋放和蛋白激酶C(PKC)的激活。CHRM3參與調(diào)節(jié)胃腸道蠕動(dòng)、腺體分泌、心臟節(jié)律、血管舒張等生理過程,同時(shí)在哮喘、腸易激綜合癥、心血管疾病等病理狀態(tài)下也發(fā)揮作用,是藥物開發(fā)和疾病治療中的潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Muscarinic acetylcholine receptor M3 (CHRM3), partial (CSB-EP005383HUb0)

驗(yàn)證數(shù)據(jù)

CSB-EP005383HUb0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CHRM3 Recombinant Monoclonal Antibody (CSB-RA827961A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA827961A0HU

IHC image of CSB-RA827961A0HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

CSB-RA827961A0HU

IHC image of CSB-RA827961A0HU diluted at 1:300 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

CHRM3 Antibodies

CHRM3 for Homo sapiens (Human)

CHRM3 Proteins

CHRM3 Proteins for Sus scrofa (Pig)

CHRM3 Proteins for Homo sapiens (Human)

CHRM3 Proteins for Bos taurus (Bovine)

CHRM3 Proteins for Gallus gallus (Chicken)

CHRM3 Proteins for Rattus norvegicus (Rat)

CHRM3 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

CHRM3 Proteins for Mus musculus (Mouse)

CHRM3 Proteins for Pongo pygmaeus (Bornean orangutan)

CHRM3 Proteins for Pan troglodytes (Chimpanzee)