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CEACAM5

CEACAM5,即癌胚抗原細(xì)胞黏附分子5,別名CD66e,由人類CEACAM5基因編碼,該基因位于染色體19q13.2,基因長(zhǎng)度約為21kb,由9個(gè)外顯子和3個(gè)非編碼外顯子組成。CEACAM5通過(guò)糖基磷脂酰肌醇(GPI)與膜結(jié)合,胞外共有7個(gè)免疫球蛋白樣結(jié)構(gòu)域,包括一個(gè)可變(IgV)樣結(jié)構(gòu)域和6個(gè)IgC樣結(jié)構(gòu)域(A1-B3)。
CEACAM5在多種生物學(xué)過(guò)程中發(fā)揮作用,包括細(xì)胞黏附、細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)和免疫調(diào)節(jié)等,并在許多惡性腫瘤細(xì)胞中高表達(dá),被廣泛用于癌癥的診斷和監(jiān)測(cè)。CEACAM5的表達(dá)異常與多種癌癥的發(fā)生發(fā)展相關(guān),尤其在結(jié)直腸癌、胃癌、肺癌和胰腺癌中過(guò)表達(dá),是潛在的癌癥治療靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) (CSB-MP005165HU)

驗(yàn)證數(shù)據(jù)

CSB-MP005165HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP005165HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM5 at 2μg/mL can bind Anti-CEACAM5 recombinant antibody (CSB-RA005165MA1HU), the EC50 is 0.8955-1.719 ng/mL.

Recombinant Macaca mulatta Carcinoembryonic antigen-related cell adhesion molecule 5(CEACAM5),partial (Active) (CSB-MP5152MOW)

驗(yàn)證數(shù)據(jù)

CSB-MP5152MOW

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP5152MOW

Activity
Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus CEACAM5 at 2μg/ml can bind Anti-CEACAM5 recombinant antibody (CSB-RA005165MA4HU). The EC50 is 3.572-4.044 ng/mL.

CSB-MP5152MOW

The purity of CEACAM5 was greater than 95% as determined by SEC-HPLC

CEACAM5 Recombinant Monoclonal Antibody (CSB-RA005165MA3HU)

驗(yàn)證數(shù)據(jù)

CSB-RA005165MA3HU

Immunofluorescence staining of Hela cell with CSB-RA005165MA3HU at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-human IgG(H+L).

CSB-RA005165MA3HU

Immunofluorescence staining of MCF7 cell with CSB-RA005165MA3HU at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-human IgG(H+L).

CSB-RA005165MA3HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA005165MA3HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was human IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,026 events was performed.

CEACAM5 Antibodies

CEACAM5 for H

CEACAM5 for Homo sapiens (Human)

CEACAM5 Proteins

CEACAM5 Proteins for Homo sapiens (Human)

CEACAM5 Proteins for Mus musculus (Mouse)

CEACAM5 ELISA Kit

CEACAM5 ELISA Kit for Homo sapiens (Human)

CEACAM5 ELISA Kit for Mus musculus (Mouse)