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CCR8

CCR8,即C-C基序趨化因子受體8,別名CD198、ChemR1、CKRL1、CKR-L1、CY6、GPRCL1、GPRCY6、GPR-CY6、TER-1等。CCR8是一種七次跨膜G蛋白偶聯受體,屬于趨化因子受體C-C亞家族。CCR8的作用機制涉及與其配體CCL1、CCL8、CCL16和CCL18的結合,其中CCL1是其主要配體。這些相互作用參與了多種腫瘤的發展進程及介導腫瘤的免疫逃逸。CCR8主要在腫瘤微環境中的調節性T細胞(Treg)上特異性高表達,而在周圍正常組織和外周血中低表達,因此CCR8可以作為Treg細胞的一種特異性標志物,是一種有潛力的治療靶點和生物標志物。CCR8的高表達與多種癌癥相關,包括結直腸癌、乳腺癌、胃癌等,被認為是腫瘤部位Treg的潛在特異性標記物,是極具潛力的腫瘤免疫靶點。

熱銷產品

Recombinant Human C-C chemokine receptor type 8 (CCR8) (CSB-CF004847HU)

驗證數據

CSB-CF004847HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CCR8 Recombinant Monoclonal Antibody (CSB-RA004847A1HU)

驗證數據

CSB-RA004847A1HU

Untransfected HEK293T cells surface (green line) and transfected Human CCR8 HEK293T stable cells surface (red line) were stained with anti-CCR8 antibody (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CCR8 Recombinant Monoclonal Antibody (CSB-RA004847MA3HU)

驗證數據

CSB-RA004847MA3HU

Untransfected CHO-K1 cells surface(green line) and transfected Human CCR8 CHO-K1 stable cells surface (red line) were stained with anti-CCR8 antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA004847MA3HU

The Binding Activity of CCR8 with Anti-CCR8 recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CCR8 (CSB-MP004847HU) at 5 μg/mL can bind Anti-CCR8 recombinant antibody, the EC50 is 11.20-15.63 ng/mL.

CCR8 Antibodies

CCR8 for Homo sapiens (Human)

CCR8 Proteins

CCR8 Proteins for Homo sapiens (Human)

CCR8 Proteins for Mus musculus (Mouse)

CCR8 Proteins for Macaca mulatta (Rhesus macaque)