CCR7
CCR7全稱為C-C趨化因子受體7型，也被稱為CD197，是趨化因子受體家族的重要成員。CCR7通過(guò)與配體CCL19和CCL21結(jié)合，引導(dǎo)淋巴細(xì)胞定向遷移至次級(jí)淋巴器官，對(duì)維持免疫系統(tǒng)穩(wěn)態(tài)具有關(guān)鍵作用。CCR7在樹突狀細(xì)胞成熟過(guò)程中表達(dá)上調(diào)，幫助抗原呈遞細(xì)胞精準(zhǔn)定位至淋巴結(jié)，從而啟動(dòng)適應(yīng)性免疫應(yīng)答。臨床上，CCR7的異常表達(dá)與多種疾病密切相關(guān)，在乳腺癌、黑色素瘤等惡性腫瘤中，癌細(xì)胞通過(guò)激活該受體實(shí)現(xiàn)淋巴結(jié)轉(zhuǎn)移；而在類風(fēng)濕性關(guān)節(jié)炎患者中，CCR7過(guò)度活化會(huì)促使炎癥細(xì)胞浸潤(rùn)關(guān)節(jié)滑膜。針對(duì)CCR7的藥物開發(fā)聚焦于腫瘤免疫治療領(lǐng)域，已有小分子拮抗劑在動(dòng)物模型中成功阻斷腫瘤轉(zhuǎn)移，但進(jìn)入臨床階段的候選藥物仍較少。利用單克隆抗體阻斷CCR7-配體相互作用的新型療法，在治療自身免疫性疾病方面展現(xiàn)出潛在價(jià)值，相關(guān)研究正在從實(shí)驗(yàn)室向轉(zhuǎn)化醫(yī)學(xué)推進(jìn)。
熱銷產(chǎn)品
Recombinant Human C-C chemokine receptor type 7 (CCR7), partial (CSB-EP004846HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CCR7 Antibody (CSB-PA004846LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry analysis of human lung tissue using CSB-PA004846LA01HU at dilution of 1:100
Immunocytochemistry analysis of human tonsil tissue using CSB-PA004846LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA004846LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CCR7 Antibodies
CCR7 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006996 | CCR7 Antibody | Human,Monkey | WB, IF, ELISA |
| CSB-PA265889 | CCR7 Antibody | Human | ELISA,WB |
| CSB-PA004846LA01HU | CCR7 Antibody | Human | ELISA, IHC, IF |
| CSB-PA004846LB01HU | CCR7 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004846LC01HU | CCR7 Antibody, FITC conjugated | Human | |
| CSB-PA004846LD01HU | CCR7 Antibody, Biotin conjugated | Human | ELISA |
CCR7 Proteins
CCR7 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004846HU1 CSB-BP004846HU1 CSB-MP004846HU1 CSB-EP004846HU1-B |
Recombinant Human C-C chemokine receptor type 7 (CCR7), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004846HU | Recombinant Human C-C chemokine receptor type 7 (CCR7) | in vitro E.coli expression system |
| CSB-EP004846HU1 | Recombinant Human C-C chemokine receptor type 7 (CCR7), partial | E.coli |
| CSB-CF004846HUa0 | Recombinant Human C-C chemokine receptor type 7 (CCR7) | in vitro E.coli expression system |
CCR7 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004846MO1 CSB-EP004846MO1 CSB-BP004846MO1 CSB-MP004846MO1 CSB-EP004846MO1-B |
Recombinant Mouse C-C chemokine receptor type 7 (Ccr7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004846MO | Recombinant Mouse C-C chemokine receptor type 7 (Ccr7) | in vitro E.coli expression system |
CCR7 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP711736BO CSB-EP711736BO CSB-BP711736BO CSB-MP711736BO CSB-EP711736BO-B |
Recombinant Bovine C-C chemokine receptor type 7 (CCR7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
