BRCA1
BRCA1，即乳腺癌易感基因1，別名FANCS、PSCP。它是由人類BRCA1基因編碼的，該基因位于17號染色體的q21位置。BRCA1是一種核磷蛋白，作為腫瘤抑制因子發(fā)揮作用，參與多種細(xì)胞過程，包括轉(zhuǎn)錄、DNA雙鏈斷裂的修復(fù)和重組。BRCA1的作用機(jī)制涉及與多種蛋白質(zhì)相互作用，形成BRCA1相關(guān)基因組監(jiān)測復(fù)合物（BASC），參與DNA損傷修復(fù)和細(xì)胞周期調(diào)控。BRCA1-BARD1異二聚體表現(xiàn)出E3Ub連接酶活性，參與DNA末端切除和DNA保護(hù)。BRCA1對維持基因組穩(wěn)定性至關(guān)重要，其突變可導(dǎo)致遺傳性乳腺癌和卵巢癌，影響約40%的遺傳性乳腺癌和80%以上的遺傳性乳腺癌和卵巢癌。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
Western Blot analysis of 293 cells using BRCA1 Polyclonal Antibody
Western Blot analysis of 823 293-UV 22RV1 cells using BRCA1 Polyclonal Antibody
BRCA1 Antibodies
BRCA1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA09659A0Rb | BRCA1 Antibody | Human | ELISA |
| CSB-PA09659B0Rb | BRCA1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA09659D0Rb | BRCA1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA002794GA01HU | BRCA1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA596474 | Phospho-BRCA1 (Ser1524) Antibody | Human | ELISA,IHC |
| CSB-PA234605 | Phospho-BRCA1 (Ser1423) Antibody | Human | ELISA,WB,IHC |
| CSB-PA904513 | BRCA1 (Ab-1524) Antibody | Human | ELISA,WB,IF |
| CSB-PA186422 | BRCA1 (Ab-1423) Antibody | Human | ELISA,WB,IHC |
| CSB-PA901818 | Phospho-BRCA1 (Ser988) Antibody | Human | ELISA,IF |
| CSB-PA258596 | Phospho-BRCA1 (Ser1457) Antibody | Human | ELISA,WB |
| CSB-PA001041 | BRCA1 Antibody | Human | WB, IHC, ELISA |
| CSB-PA001042 | BRCA1 Antibody | Human,Rat | WB, IHC, IF, ELISA |
| CSB-PA050135 | Phospho-BRCA1 (S1423) Antibody | Human,Rat | WB, IHC, ELISA |
| CSB-PA050136 | Phospho-BRCA1 (S1524) Antibody | Human | IHC, ELISA |
| CSB-PA050137 | Phospho-BRCA1 (S1457) Antibody | Human | WB, ELISA |
| CSB-PA050138 | BRCA1 Antibody | Human | WB, ELISA |
| CSB-PA050139 | BRCA1 Antibody | Human | IHC, ELISA |
| CSB-PA291937 | BRCA1 Antibody | Human | ELISA,IHC |
| CSB-PA678542 | BRCA1 Antibody | Human | ELISA,IHC |
BRCA1 Proteins
BRCA1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002794HU CSB-BP002794HU CSB-MP002794HU CSB-EP002794HU-B |
Recombinant Human Breast cancer type 1 susceptibility protein (BRCA1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002794HU | Recombinant Human Breast cancer type 1 susceptibility protein (BRCA1), partial | E.coli |
BRCA1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP344548MO CSB-EP344548MO CSB-BP344548MO CSB-MP344548MO CSB-EP344548MO-B |
Recombinant Mouse Breast cancer type 1 susceptibility protein homolog (Brca1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP526320RA CSB-EP526320RA CSB-BP526320RA CSB-MP526320RA CSB-EP526320RA-B |
Recombinant Rat Breast cancer type 1 susceptibility protein homolog (Brca1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP740265MOW CSB-EP740265MOW CSB-BP740265MOW CSB-MP740265MOW CSB-EP740265MOW-B |
Recombinant Macaca mulatta Breast cancer type 1 susceptibility protein homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Pongo pygmaeus (Bornean orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP743602EXP CSB-EP743602EXP CSB-BP743602EXP CSB-MP743602EXP CSB-EP743602EXP-B |
Recombinant Pongo pygmaeus Breast cancer type 1 susceptibility protein homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP753729GGZ CSB-EP753729GGZ CSB-BP753729GGZ CSB-MP753729GGZ CSB-EP753729GGZ-B |
Recombinant Gorilla gorilla gorilla Breast cancer type 1 susceptibility protein homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP769686BO CSB-EP769686BO CSB-BP769686BO CSB-MP769686BO CSB-EP769686BO-B |
Recombinant Bovine Breast cancer type 1 susceptibility protein homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP839156DO CSB-EP839156DO CSB-BP839156DO CSB-MP839156DO CSB-EP839156DO-B |
Recombinant Dog Breast cancer type 1 susceptibility protein homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP844583DOA CSB-EP844583DOA CSB-BP844583DOA CSB-MP844583DOA CSB-EP844583DOA-B |
Recombinant Arabidopsis thaliana Protein BREAST CANCER SUSCEPTIBILITY 1 homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP861936EQV CSB-EP861936EQV CSB-BP861936EQV CSB-MP861936EQV CSB-EP861936EQV-B |
Recombinant Pan troglodytes Breast cancer type 1 susceptibility protein homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
