BFAR
BFAR，即雙功能凋亡調(diào)節(jié)因子，別名BAR、RNF47。BFAR是一個多結(jié)構(gòu)域的E3泛素連接酶，它通過結(jié)合半胱天冬酶、蛋白質(zhì)-大分子銜接活性以及泛素蛋白連接酶活性，參與IRE1介導(dǎo)的未折疊蛋白反應(yīng)的負(fù)調(diào)控、蛋白酶體介導(dǎo)的泛素依賴性蛋白質(zhì)分解代謝過程以及蛋白質(zhì)泛素化。BFAR在細(xì)胞凋亡過程的負(fù)調(diào)節(jié)中起作用，并且位于內(nèi)質(zhì)網(wǎng)和膜內(nèi)。BFAR的異常表達(dá)與多種疾病相關(guān)，包括腫瘤，其中在老年個體來源的CD8+ T細(xì)胞中高表達(dá)會抑制TRM細(xì)胞的產(chǎn)生，影響機體抗腫瘤免疫反應(yīng)。
熱銷產(chǎn)品
BFAR Antibody (CSB-PA002678ESR1HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA002678ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA002678ESR1HU at dilution of 1:100
BFAR Antibodies
BFAR for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA239397 | BFAR Antibody | Human | ELISA,IHC |
| CSB-PA217827 | BFAR Antibody | Human | ELISA,IHC |
| CSB-PA002678ESR1HU | BFAR Antibody | Human | ELISA, IHC |
BFAR Proteins
BFAR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002678HU1 CSB-EP002678HU1 CSB-BP002678HU1 CSB-MP002678HU1 CSB-EP002678HU1-B |
Recombinant Human Bifunctional apoptosis regulator (BFAR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002678HU | Recombinant Human Bifunctional apoptosis regulator (BFAR) | in vitro E.coli expression system |
