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BABAM2

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX . In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.

BABAM2 Antibodies

BABAM2 for Homo sapiens (Human)

BABAM2 Proteins

BABAM2 Proteins for Bos taurus (Bovine)

BABAM2 Proteins for Branchiostoma floridae (Florida lancelet) (Amphioxus)

BABAM2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

BABAM2 Proteins for Pongo abelii (Sumatran orangutan)

BABAM2 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

BABAM2 Proteins for Gallus gallus (Chicken)

BABAM2 Proteins for Mesocricetus auratus (Golden hamster)

BABAM2 Proteins for Rattus norvegicus (Rat)

BABAM2 Proteins for Xenopus laevis (African clawed frog)

BABAM2 Proteins for Mus musculus (Mouse)

BABAM2 Proteins for Saguinus oedipus (Cotton-top tamarin)

BABAM2 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

BABAM2 Proteins for Homo sapiens (Human)