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Your Good Partner in Biology Research

ATM

ATM,即共濟(jì)失調(diào)毛細(xì)血管擴(kuò)張癥突變蛋白,別名A-TM。它是一種絲氨酸/蘇氨酸蛋白激酶,屬于PI3K樣蛋白激酶(PIKKs)家族成員之一。ATM主要在細(xì)胞核中表達(dá),其編碼基因位于人類第11號(hào)染色體上。ATM的作用機(jī)制涉及對(duì)DNA雙鏈斷裂(DSB)的響應(yīng),通過磷酸化多種底物蛋白,包括p53、Chk2、BRCA1等,從而激活細(xì)胞周期檢查點(diǎn)、促進(jìn)DNA修復(fù)和誘導(dǎo)細(xì)胞凋亡。ATM在維持基因組穩(wěn)定性、防止腫瘤發(fā)生以及對(duì)電離輻射和化療藥物的響應(yīng)中發(fā)揮關(guān)鍵作用,其功能喪失會(huì)導(dǎo)致Ataxia-telangiectasia(A-T)疾病,表現(xiàn)為神經(jīng)系統(tǒng)退化、癌癥易感性增加和免疫功能障礙。

熱銷產(chǎn)品

ATM Recombinant Monoclonal Antibody (CSB-RA166706A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA166706A0HU

IHC image of CSB-RA166706A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA166706A0HU

IHC image of CSB-RA166706A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA166706A0HU

Overlay histogram showing Hela cells stained with CSB-RA166706A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.

ATM Antibodies

ATM for Homo sapiens (Human)

ATM Proteins

ATM Proteins for Homo sapiens (Human)

ATM Proteins for Mus musculus (Mouse)

ATM Proteins for Sus scrofa (Pig)

ATM Proteins for Arabidopsis thaliana (Mouse-ear cress)