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AQP4

AQP4,即水通道蛋白4,別名MGC22454、MIWC、WCH4。AQP4主要在中樞神經系統的星形膠質細胞中表達,尤其在細胞終足部分,對維持腦內水和鉀離子平衡發揮關鍵作用。AQP4的作用機制涉及形成水分子的通道,允許水分子根據滲透梯度快速通過細胞膜,從而參與調節腦脊液的產生、內環境穩定以及神經系統的水和鉀離子平衡。AQP4參與了多種神經系統疾病的發生發展,如腦水腫、缺血性腦卒中、神經炎癥等,其表達水平的變化與疾病的嚴重程度和預后密切相關。AQP4還與視神經脊髓炎譜系疾病(NMOSD)緊密相關,AQP4抗體陽性患者的病變分布與AQP4的分布高度相關,特征性病灶位于視神經、脊髓、間腦和后腦區。AQP4在中樞神經系統疾病的診斷和治療中具有重要的生物學意義。

熱銷產品

Recombinant Human Aquaporin-4 (AQP4), partial (CSB-EP001964HU)

驗證數據

CSB-EP001964HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

AQP4 Recombinant Monoclonal Antibody (CSB-RA548145A0HU)

驗證數據

CSB-RA548145A0HU

IHC image of CSB-RA548145A0HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.33% DAB.

AQP4 Antibodies

AQP4 for Homo sapiens (Human)

AQP4 for H, M, R

AQP4 Proteins

AQP4 Proteins for Homo sapiens (Human)

AQP4 ELISA Kit

AQP4 ELISA Kit for Homo sapiens (Human)