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AKT2

AKT2,即蛋白激酶Bβ,是一種在細胞內信號傳導中發揮重要作用的絲氨酸/蘇氨酸激酶。AKT2主要在胰島素敏感的組織如骨骼肌、脂肪和肝臟中表達,是PI3K/AKT信號通路的關鍵組成部分。其作用機制涉及PI3K產生的PIP3,該物質能夠招募AKT2至細胞膜,并通過磷酸化激活AKT2。激活后的AKT2能夠磷酸化多種底物,包括FOXO轉錄因子、mTOR復合體等,從而調控細胞的生長、代謝、存活和凋亡。AKT2參與的信號通路包括胰島素信號通路、IGF-1信號通路等,這些通路在調節細胞對營養物質的吸收、利用以及能量平衡中起著核心作用。AKT2還與細胞周期的調控、細胞應激反應和細胞遷移等過程密切相關。在生物學意義上,AKT2對于維持細胞的正常生理功能和代謝平衡至關重要。其異常激活與2型糖尿病、肥胖和某些類型的癌癥等代謝性疾病和腫瘤的發生發展有關,是這些疾病治療中的潛在靶點。

熱銷產品

Recombinant Mouse RAC-beta serine/threonine-protein kinase (Akt2) (CSB-EP717138MO)

驗證數據

CSB-EP717138MO

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

AKT2 Antibody (CSB-PA15919A0Rb)

驗證數據

CSB-PA15919A0Rb

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Rat liver tissue
All lanes: AKT2 antibody at 2.8µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56, 52 kDa
Observed band size: 56 kDa

CSB-PA15919A0Rb

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA15919A0Rb at dilution of 1:100

CSB-PA15919A0Rb

Immunofluorescence staining of A549 cells with CSB-PA15919A0Rb at 1:466, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

AKT2 Antibodies

AKT2 for Homo sapiens (Human)

AKT2 Proteins

AKT2 Proteins for Homo sapiens (Human)

AKT2 Proteins for Rattus norvegicus (Rat)

AKT2 Proteins for Arabidopsis thaliana (Mouse-ear cress)

AKT2 Proteins for Mus musculus (Mouse)