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Your Good Partner in Biology Research

ABL1

ABL1,別名c-Abl、p150、BCR-ABL1等。它是一種由ABL1基因編碼的非受體酪氨酸激酶,主要在各種細胞中表達,包括造血細胞。ABL1的作用機制涉及多種生物學過程,包括細胞信號傳導、細胞周期控制、細胞分化和凋亡。在細胞中,ABL1通過磷酸化多種底物蛋白來調控信號轉導途徑,影響細胞的生長、運動和存活。ABL1的異常激活與多種癌癥的發(fā)生發(fā)展相關,尤其是與費城染色體陽性的慢性髓性白血病(CML)有關,這是由于ABL1基因與BCR基因的融合導致的。這種融合蛋白具有持續(xù)的酪氨酸激酶活性,導致細胞失控增殖。ABL1也是多種癌癥治療藥物的靶點,如伊馬替尼(Imatinib),它通過抑制ABL1的激酶活性來治療CML和其他ABL1相關的癌癥。

熱銷產品

Recombinant Human Tyrosine-protein kinase ABL1 (ABL1), partial (CSB-RP043554h)

驗證數據

CSB-RP043554h

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ABL1 Antibody (CSB-PA04355A0Rb)

驗證數據

CSB-PA04355A0Rb

IHC image of CSB-PA04355A0Rb diluted at 1:1200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA04355A0Rb

Immunoprecipitating ABL1 in Hela whole cell lysate
Lane 1: Rabbit control IgG (1µg) instead of CSB-PA04355A0Rb in Hela whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA04355A0Rb (6µg) + Hela whole cell lysate (500µg)
Lane 3: Hela whole cell lysate (10µg)

Human Tyrosine-protein kinase ABL1(ABL1) ELISA kit (CSB-EL001105HU)

驗證數據

CSB-EL001105HU 標準曲線

貨號:CSB-EL001105HU

規(guī)格:96T/48T

靈敏度:6.25 pg/mL

檢測范圍:25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ABL1 Antibodies

ABL1 for Homo sapiens (Human)

ABL1 Proteins

ABL1 Proteins for Homo sapiens (Human)

ABL1 Proteins for Mus musculus (Mouse)

ABL1 ELISA Kit

ABL1 ELISA Kit for Homo sapiens (Human)