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  4. Recombinant Human Transmembrane protein 59 (TMEM59)-VLPs

Recombinant Human Transmembrane protein 59 (TMEM59)-VLPs

  • 中文名稱：
    人TMEM59重組蛋白
  • 貨號(hào)：
    CSB-MP023860HU
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 其他：

產(chǎn)品詳情

  • 基因名：
    TMEM59
  • Uniprot No.：
  • 別名：
    TMEM59; C1orf8; HSPC001; UNQ169/PRO195; Transmembrane protein 59; Liver membrane-bound protein
  • 種屬：
    Homo sapiens (Human)
  • 來(lái)源：
    Mammalian cell
  • 表達(dá)區(qū)域：
    37-323aa
  • 氨基酸序列
    AFDSVLGDTASCHRACQLTYPLHTYPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQLPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIFQSKPEIQYAPHLEQEPTNLRESSLSKMSYLQMRNSQAHRNFLEDGESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLPTKVNLAHSEI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it’s possible to develop.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will default ship it in lyophilized form with normal bule ice packs. However, if you request to ship in liquid form, it needs to be shipped with dry ice, please communicate with us in advance and extra fees for dry ice and dry ice box will be charged.
  • 緩沖液：
    Lyophilized from PBS, 6% Trehalose, pH 7.4
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store the protein at -20°C/-80°C upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
  • 基因功能參考文獻(xiàn)：
    1. identify the single-span membrane protein TMEM59 as an interactor of FZD and LRP6 and a positive regulator of Wnt signaling. Mechanistically, TMEM59 promotes the formation of multimeric Wnt-FZD assemblies via intramembrane interactions. PMID: 29632210
    2. DCF1 subcellular localization and its function in mitochondria PMID: 29074393
    3. The TMEM59 gene identified from our discovery approach was recently implicated in amyloid-beta protein precursor post-translational processing, supporting a role for epigenetic change in LOAD pathology. PMID: 22451312
    4. TMEM59 affects amyloid precursor protein shedding by reducing its acccess to cellular components. PMID: 20427278
  • 亞細(xì)胞定位：
    Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    TMEM59 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1239

    KEGG: hsa:9528

    STRING: 9606.ENSP00000234831

    UniGene: Hs.118947