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  4. Recombinant Staphylococcus aureus Clumping factor A (clfA), partial

Recombinant Staphylococcus aureus Clumping factor A (clfA), partial

In Stock
  • 中文名稱：
    Recombinant Staphylococcus aureus Clumping factor A(clfA),partial
  • 品名簡稱：
    Recombinant Staphylococcus aureus clfA protein, partial
  • 貨號：
    CSB-EP753416SKWe1
  • 說明書：
  • 規格：
    ￥3324
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    clfA
  • Uniprot No.：
  • 別名：
    clfA; SAS0752; Clumping factor A; Fibrinogen receptor A; Fibrinogen-binding protein A
  • 種屬：
    Staphylococcus aureus (strain MSSA476)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    36.1kDa
  • 表達區域：
    228-558aa
  • 氨基酸序列
    GKDITNQLTNVTVGIDSGDTVYPHQAGYVKLNYGFSVPNSAVKGDTFKITVPKELNLNGVTSTAKVPPIMAGDQVLANGVIDSDGNVIYTFTDYVDTKENVTANITMPAYIDPENVTKTGNVTLTTGIGSTTANKTVLVDYEKYGKFYNLSIKGTIDQIDKTNNTYRQTIYVNPSGDNVIAPVLTGNLKPNTDSNALIDQQNTSIKVYKVDNAADLSESYFVNPENFEDVTNSVNITFPNPNQYKVEFNTPDDQITTPYIVVVNGHIDPNSKGDLALRSTLYGYDSRFVWRSMSWDNEVAFNNGSGSGDGIDKPVVPEQPDEPGEIEPIPE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    Tag-Free
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產品描述：

    The expression of recombinant Staphylococcus aureus clfA protein includes the construction of the expression vector containing the recombinant DNA and the transformation of the expression vector into the E.coli, which provides a variety of macromolecules and components required for transcription and translation. The recombinant DNA encodes the 228-558aa of the Staphylococcus aureus clfA protein. This N-terminal 6xHis-tagged recombinant Staphylococcus aureus clfA protein is also characterized by high purity, >90%. Under SDS-PAGE condition, this recombinant clfA protein migrated to the band of about 36 kDa molecular weight.

    ClfA is a virulence factor from Staphylococcus aureus. As a virulence factor, ClfA is an important virulence factor that promotes the pathogenesis of the diseases and can be a target for generation of vaccine against S. aureus infections. As the targeted protein is highly antigenic and conserved, hence the designed novel vaccine construct holds potential against emerging multi-drug-resistant organisms. Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia. B. There are many distinct virulence factors related to the disease establishment. In Staphylococcus spp. factors such as the fibronectin-binding proteins (fnbA and fnbB), elastin binding proteins (ebpS), clumping factors (clfA and clfB), and collagen-binding protein (cna) play important roles in binding to host cells, colonization, and invasion. Sortase A is an essential virulence factor of S. aureus, which is responsible for the determinants, which can escape host immune response and cause a series of diseases. SrtA mediates anchoring of several adhesion-related proteins, such as ClfA/ClfB.

  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps.
  • 亞細胞定位：
    Secreted, cell wall; Peptidoglycan-anchor.
  • 蛋白家族：
    Serine-aspartate repeat-containing protein (SDr) family
  • 數據庫鏈接：

    KEGG: sas:SAS0752