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  4. Recombinant Rat Insulin-like growth factor-binding protein 4 (Igfbp4)

Recombinant Rat Insulin-like growth factor-binding protein 4 (Igfbp4)

  • 中文名稱：
    大鼠Igfbp4重組蛋白
  • 貨號：
    CSB-YP011098RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Igfbp4重組蛋白
  • 貨號：
    CSB-EP011098RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Igfbp4重組蛋白
  • 貨號：
    CSB-EP011098RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Igfbp4重組蛋白
  • 貨號：
    CSB-BP011098RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Igfbp4重組蛋白
  • 貨號：
    CSB-MP011098RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Igfbp4
  • Uniprot No.：
  • 別名：
    Igfbp4; Igfbp-4Insulin-like growth factor-binding protein 4; IBP-4; IGF-binding protein 4; IGFBP-4
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    22-254
  • 氨基酸序列
    DEAIHCPPC SEEKLARCRP PVGCEELVRE PGCGCCATCA LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC TELSEIEAIQ ESLQTSDKDE SEHPNNSFNP CSAHDHRCLQ KHMAKVRDRS KMKVVGTPRE EPRPVPQGSC QSELHRALER LAASQSRTHE DLFIIPIPNC DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK GELDCHQLAD SLQE
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 基因功能參考文獻：
    1. various inflammatory insults decrease muscle IGFBP-5 mRNA, without altering IGFBP-4, by a TNF-dependent glucocorticoid-independent mechanism. PMID: 16339387
    2. The temporal expression pattern of IGFBP-4 in the embryonic brain suggests an important role of IGFBP-4 in regulating differentiation of neural stem cells PMID: 24175938
    3. IGFBP-4 expression is induced in hepatoma cells by the dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). PMID: 23639626
    4. knockdown results in decreased differentiation potential of mesenchymal stromal cells PMID: 21846294
    5. Overexpression of pulmonary IGFBP-4 during the later stages of lung development may contribute to pulmonary hypoplasia PMID: 20938897
    6. five different glycosylation isoforms of the protein PMID: 12162998
    7. data establish a role for hormonal factors such as thyronines and retinoids in regulating the hepatic IGF system directly at the insulin-like growth factor binding protein(IGFBP)-4 level PMID: 14983400
    8. Data suggested that growth factor- and cytokine-mediated changes in IGFBP abundance regulate postnatal fibroblast cell. proliferation PMID: 15204833

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  • 亞細胞定位：
    Secreted.
  • 數(shù)據(jù)庫鏈接：