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  4. Recombinant Mouse Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform(Ppp3cb)

Recombinant Mouse Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform(Ppp3cb)

  • 中文名稱：
    Recombinant Mouse Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform(Ppp3cb)
  • 品名簡稱：
    Recombinant Mouse Ppp3cb protein
  • 貨號：
    CSB-EP018573MO
  • 說明書：
  • 規格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 別名：
    CAM-PRP catalytic subunit;Calmodulin-dependent calcineurin A subunit beta isoform
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    65.9 kDa
  • 表達區域：
    2-525aa
  • 氨基酸序列
    AAPEPARAAPPPPPPPPPPLGADRVVKAVPFPPTHRLTSEEVFDMDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHTTENHGTGNHSAQ
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    C-terminal 6xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.
  • 基因功能參考文獻：
    1. Transient high ductal pressure produces pancreatic inflammation and loss of tight junction integrity via calcineurin signaling. PMID: 29928898
    2. CnAbeta1 is mainly localized at the Golgi apparatus through its C-terminal domain. CnAbeta1 is needed for mTORC2 localization and activation at the cellular membranes. CnAbeta1 regulates differentiation of mouse embryonic stem cells to mesoderm. PMID: 27746127
    3. CaM plays an active role in shaping both the spatial and temporal aspects of calcineurin-mediated calcium signaling. PMID: 25056880
    4. loss of beta isoform of calcineurin is sufficient to reproduce aspects of cyclosporine on diabetic renal hypertrophy but not matrix expansion; calcineurin beta appears to be a central mechanism involved in organ hypertrophy PMID: 19778355
    5. Calcineurin Abeta1 shows a unique mode of action that improves cardiac function after myocardial infarction, activating different cardioprotective pathways without inducing maladaptive hypertrophy PMID: 21632490
    6. A novel-splicing variant of calcineurin Ass CnAss-FK, which is encoded by an intron-retaining mRNA and is deficient in the autoinhibitory domain, is predominantly expressed in mature follicular keratinocytes. PMID: 21423799
    7. Calcineurin Abeta is important for the production and maintenance of Treg cells and to ensure mature T-cell quiescence. PMID: 21256088
    8. Results identify a novel signaling process governing G-protein-coupled cAMP signal transduction-opposing actions of the phosphatase calcineurin and the CK1/GSK3beta protein kinases on the phosphodegron-dependent degradation of PDE4D. PMID: 20647544
    9. Total peripheral T cell numbers were significantly reduced in CnA beta(-/-) mice and were defective in proliferative capacity and IL-2 production in response to PMA/ionomycin and T cell receptor cross-linking. PMID: 12091710
    10. Calcineurin Abeta knockout mice predisposes the myocardium to acute mycardial reperfusion injury. PMID: 14615291
    11. CnAbeta is also required for the homeostatic survival of naive T cells. PMID: 18097009
    12. Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation. PMID: 19074476

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    PPP phosphatase family, PP-2B subfamily
  • 組織特異性：
    Expressed in kidney, in the thick ascending limb epithelium and in the collecting duct, but not in the distal convoluted tubule (at protein level).
  • 數據庫鏈接：