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  4. Rat α1-Acid glycoprotein(α1-AGP) ELISA Kit

Rat α1-Acid glycoprotein(α1-AGP) ELISA Kit

  • 中文名稱：
    大鼠α1酸性糖蛋白(α1-AGP)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E12730r
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3800/￥2500
  • 促銷：
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠α1酸性糖蛋白(α1-AGP)酶聯(lián)免疫試劑盒（CSB-E12730r）為競爭法ELISA試劑盒，定量檢測血清、血漿、尿液、組織培養(yǎng)上清液、組織勻漿樣本中的ORM1含量。ORM1即阿片受體μ樣1，是一種重要的藥物靶點(diǎn)。研究發(fā)現(xiàn)它參與痛覺調(diào)節(jié)、情緒調(diào)控等生理過程。其機(jī)制主要在于與內(nèi)源性配體結(jié)合后，通過一系列信號轉(zhuǎn)導(dǎo)影響細(xì)胞功能，在鎮(zhèn)痛、精神疾病治療等方面有潛在研究價值。試劑盒檢測范圍為3.125 ng/mL-800 ng/mL，具備高靈敏度和特異性，適用于炎癥相關(guān)機(jī)制研究、藥物干預(yù)效果評價或疾病動物模型中的生物標(biāo)志物分析等科研場景，實(shí)驗(yàn)操作流程標(biāo)準(zhǔn)化，配套試劑完整，可滿足實(shí)驗(yàn)室常規(guī)檢測需求。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Orm1Alpha-1-acid glycoprotein ELISA kit; Orosomucoid ELISA kit; OMD ELISA kit
  • 縮寫：
    ORM1
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, urine, cell culture supernates, tissue homogenates
  • 檢測范圍：
    3.125 ng/mL-800 ng/mL
  • 靈敏度：
    3.125 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Competitive
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat α1-AGP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1000 Average % 95
    Range % 85-105
    1:2000 Average % 89
    Range % 81-98
    1:4000 Average % 90
    Range % 82-97
    1:8000 Average % 95
    Range % 83-98
  • 回收率：
    The recovery of rat α1-AGP spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 95 89-102
    EDTA plasma (n=4) 95 90-99
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average
    800 0.213 0.217 0.215
    200 0.459 0.453 0.456
    50 0.851 0.859 0.855
    12.5 1.226 1.246 1.236
    3.125 1.727 1.740 1.734
    0 1.935 1.958 1.947
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
  • 基因功能參考文獻(xiàn)：
    1. fatigue upregulates the level of ORM1, which in turn functions as an anti-fatigue protein to enhance muscle endurance via the CCR5 pathway. PMID: 26740279
    2. context-dependent nature of ORM1 angioregulatory function is further demonstrated in the CAM assay where ORM1 stimulates developmental angiogenesis without exerting any inhibitory activity PMID: 22916107
    3. alpha-1 acid glycoprotein expression is increased by retinoids at the transcriptional level through two distinct DR1 retinoic acid responsive elements PMID: 15157739
    4. Surprisingly, AGP-over-expressing mice were not protected against renal ischemia-reperfusion injury. PMID: 15502707
    5. Orm1 gene expression highly induced in cardiomyocytes overexpressing mineralocorticoid receptor and treated with aldosterone. PMID: 17234708

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Calycin superfamily, Lipocalin family
  • 數(shù)據(jù)庫鏈接：