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  4. Rat growth differentiation factor 15(GDF15)ELISA Kit

Rat growth differentiation factor 15(GDF15)ELISA Kit

  • 中文名稱：
    大鼠生長分化因子15(GDF15)酶聯免疫試劑盒
  • 貨號：
    CSB-E16317r
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 促銷：
  • 其他：

產品詳情

  • 產品描述：
    大鼠生長分化因子15(GDF15)酶聯免疫試劑盒（CSB-E16317r）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的GDF15含量。GDF15是一種生長分化因子。其它在多種組織中表達，與細胞生長、分化等密切相關。研究機制上，它能通過與特定受體結合參與機體能量代謝、炎癥反應等調節，在腫瘤、代謝疾病等研究中受關注。試劑盒檢測范圍為1.56 pg/mL-100 pg/mL，適用于能量代謝調控機制研究、心血管疾病動物模型評估、腫瘤相關病理分析等科研場景本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Gdf15 ELISA Kit; SbfGrowth/differentiation factor 15 ELISA Kit; GDF-15 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    1.56 pg/mL-100 pg/mL
  • 靈敏度：
    0.39 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Competitive
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat GDF in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:10Average %92
    Range %87-96
    1:20Average %83
    Range %80-86
    1:40Average %96
    Range %93-99
    1:80Average %102
    Range %99-105
  • 回收率：
    The recovery of rat GDF spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8683-90
    EDTA plasma (n=4)9389-96
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2Average
    1000.127 0.129 0.128
    500.208 0.220 0.214
    250.334 0.324 0.329
    12.50.472 0.498 0.485
    6.250.713 0.735 0.724
    3.121.162 1.139 1.151
    1.561.542 1.567 1.555
    02.814 2.864 2.839
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (Probable). On hepatocytes, inhibits growth hormone signaling.
  • 基因功能參考文獻：
    1. These findings demonstrate the importance of the AP in the mediation of cancer-dependent anorexia and body weight loss and support a pathological role of MIC-1 as a tumour-derived factor mediating CACS, possibly via an AP-dependent action. PMID: 28025863
    2. Plasma GDF-15 was increased 3, 12 and 26, while plasma TGF-beta was increased 12 weeks after irradiation. PMID: 27566082
    3. the time course of the expression of growth differentiation factor15 (GDF15) in rat ischemic myocardium with increasing durations of reperfusion, and to elucidate its physiopathological role in the noreflow phenomenon, is reported. PMID: 26647773
    4. findings indicate that the attenuation of REV-ERBalpha leads to an upregulation of Gdf10 and Gdf15 in decidual cells PMID: 26811051
    5. GDF15 protects the renal interstitium and tubular compartment in experimental type 1 and 2 diabetes without affecting glomerular damage PMID: 23986522
    6. Up-regulation of EGR-1 and NAG-1, along with higher reactive oxygen species load may positively regulate the intrinsic pathway of apoptosis for the NSAID mediated chemoprevention of colorectal cancer. PMID: 23435960
    7. Gdf15 expression exhibits increases >10-fold at night in the rat pineal gland, reaching levels that are >15-fold higher than the median in other tissues. PMID: 19103603

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 組織特異性：
    Detected in plasma (at protein level).
  • 數據庫鏈接：