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  4. Rat Serine/threonine-protein kinase TNNI3K(TNNI3K) ELISA kit

Rat Serine/threonine-protein kinase TNNI3K(TNNI3K) ELISA kit

  • 中文名稱(chēng)：
    大鼠絲氨酸/蘇氨酸蛋白激酶TNNI3K(TNNI3K)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL024014RA
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 促銷(xiāo)：
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠絲氨酸/蘇氨酸蛋白激酶TNNI3K(TNNI3K)酶聯(lián)免疫試劑盒（CSB-EL024014RA）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的TNNI3K含量。TNNI3K 是一個(gè)重要靶點(diǎn)。它在心肌相關(guān)生理病理過(guò)程中發(fā)揮作用，其異常表達(dá)或功能變化可能與心肌疾病發(fā)生發(fā)展相關(guān)。研究機(jī)制上，主要探索其在心肌細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)、心肌重塑等方面機(jī)制，以尋找潛在治療干預(yù)途徑。試劑盒檢測(cè)范圍為18.75 pg/mL-1200 pg/mL，適用于科研場(chǎng)景下對(duì)大鼠心臟疾病模型、心肌細(xì)胞信號(hào)通路調(diào)控或藥物干預(yù)實(shí)驗(yàn)中的TNNI3K動(dòng)態(tài)表達(dá)分析，適用于體外實(shí)驗(yàn)中對(duì)不同來(lái)源生物樣本的平行檢測(cè)，為探索TNNI3K在心血管生理病理過(guò)程中的作用提供可靠工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Tnni3k ELISA Kit; Cark ELISA Kit; Serine/threonine-protein kinase TNNI3K ELISA Kit; EC 2.7.11.1 ELISA Kit; Cardiac ankyrin repeat kinase ELISA Kit; TNNI3-interacting kinase ELISA Kit
  • 縮寫(xiě)：
    TNNI3K
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類(lèi)型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測(cè)范圍：
    18.75 pg/mL-1200 pg/mL
  • 靈敏度：
    4.69 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線(xiàn)性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat TNNI3K in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 91
    Range % 86-95
    1:2 Average % 102
    Range % 97-107
    1:4 Average % 91
    Range % 85-97
    1:8 Average % 97
    Range % 91-103
  • 回收率：
    The recovery of rat TNNI3K spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 95 89-98
    EDTA plasma (n=4) 97 90-100
  • 標(biāo)準(zhǔn)曲線(xiàn)：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    1200 2.465 2.561 2.513 2.401
    600 1.932 1.892 1.912 1.800
    300 1.277 1.298 1.288 1.176
    150 0.708 0.739 0.724 0.612
    75 0.412 0.432 0.422 0.310
    37.5 0.287 0.275 0.281 0.169
    18.75 0.183 0.185 0.184 0.072
    0 0.111 0.113 0.112 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role in cardiac physiology.
  • 基因功能參考文獻(xiàn)：
    1. TNNI3K may be a novel mediator of cardiac troponin I phosphorylation and contribute to the regulation of cardiac myofilament contraction function. PMID: 23369981
    2. TNNI3K promotes a concentric hypertrophy with enhancement of cardiac function via regulating the phosphorylation of cTnI PMID: 23472207
  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 數(shù)據(jù)庫(kù)鏈接：