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  4. Mouse Angiopoietin-related protein 6(ANGPTL6) ELISA kit

Mouse Angiopoietin-related protein 6(ANGPTL6) ELISA kit

  • 中文名稱：
    小鼠血管生成素相關蛋白6(ANGPTL6)酶聯免疫試劑盒
  • 貨號：
    CSB-EL001714MO
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 促銷：
  • 其他：

產品詳情

  • 產品描述：
    小鼠血管生成素相關蛋白6(ANGPTL6)酶聯免疫試劑盒（CSB-EL001714MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的ANGPTL6含量。ANGPTL6，也稱為Angiopoietin-like 6，是一種與血管生成和細胞分化相關的蛋白質編碼基因。其研究顯示，ANGPTL6基因突變與家族性顱內動脈瘤形成有關，且在冠心病患者中，ANGPTL6水平與冠狀動脈病變嚴重程度呈負相關，提示其可能作為潛在的治療靶點。試劑盒檢測范圍為62.5 pg/mL-4000 pg/mL，適用于基礎科研中探索ANGPTL6在代謝性疾病模型、血管生成機制或相關信號通路中的表達變化，為體外實驗提供高效定量分析工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Angptl6 ELISA kit; AgfAngiopoietin-related protein 6 ELISA kit; Angiopoietin-like protein 6 ELISA kit; Angiopoietin-related growth factor ELISA kit
  • 縮寫：
    ANGPTL6
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    62.5 pg/mL-4000 pg/mL
  • 靈敏度：
    15.6 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse ANGPTL6 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:100Average %89
    Range %82-96
    1:200Average %98
    Range %93-102
    1:400Average %99
    Range %95-107
    1:800Average %91
    Range %87-95
  • 回收率：
    The recovery of mouse ANGPTL6 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9184-95
    EDTA plasma (n=4)9996-105
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    40002.616 2.793 2.705 2.546
    20001.927 2.036 1.982 1.823
    10001.287 1.388 1.338 1.179
    5000.769 0.729 0.749 0.590
    2500.577 0.604 0.591 0.432
    1250.394 0.401 0.398 0.239
    62.50.247 0.267 0.257 0.098
    00.164 0.154 0.159 　
  • 數據處理：
  • 貨期：
    3-5 working days

引用文獻

產品評價

靶點詳情

  • 功能：
    May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.
  • 基因功能參考文獻：
    1. Since upregulation of ANGPTL6 is induced on metabolic stress, we investigated the hepatic expression of ANGPTL6 by leptin, a representative adipokine of obesity. Mice on a high-fat diet showed increased serum leptin levels and hepatic Angptl6 expression. PMID: 29852166
    2. Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis. PMID: 27698489
    3. mitochondrial OXPHOS function governs the expression of ANGPTL6, which is an essential factor for FGF21 production in adipose tissue and cultured adipocytes. PMID: 28184000
    4. In addition to pronounced angiogenesis and epidermal hyperplasia, marked enlargement of dermal lymphatic vessels was observed in UV-B-exposed Angptl6/AGF transgenic mice. PMID: 22132739
    5. we show that (>80%) of the AGF-deficient mice die at about embryonic day 13, while the surviving AGF-deficient mice develop marked obesity, lipid accumulation in skeletal muscle and liver, and insulin resistance accompanied by reduced energy expenditure PMID: 15778720
    6. Our results strongly suggest that AGF is an integrin ligand as well as a mitogenic growth factor and theoretically participates in cutaneous wound healing in a more complex mechanism. PMID: 16806062
    7. Activation of an ERK1/2-eNOS-NO pathway is a crucial signaling mechanism by which angiopoietin-related growth factor increases blood flow through induction of angiogenesis and arteriogenesis. PMID: 18258819

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  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Highly expressed in the liver, specifically in hepatocytes, and weakly in the heart. Expressed in hematopoietic cells, platelets and mast cells, and detected at wounded skin.
  • 數據庫鏈接：