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  4. Monkey Complement 3(C3)ELISA Kit

Monkey Complement 3(C3)ELISA Kit

  • 中文名稱：
    猴子補體蛋白3(C3)酶聯免疫試劑盒
  • 貨號：
    CSB-E16528Mk
  • 規格：
    96T/48T
  • 價格：
    ￥4200/￥3000
  • 促銷：
  • 其他：

產品詳情

  • 產品描述：
    猴子補體蛋白3(C3)酶聯免疫試劑盒（CSB-E16528Mk）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液樣本中的C3含量。C3作為靶點，是補體系統中的關鍵成分。其在免疫防御等方面發揮重要作用，異常激活會引發多種疾病。研究機制主要聚焦于調控C3激活過程，以此開發藥物干預補體過度激活，為相關疾病提供新治療策略。試劑盒檢測范圍為4.68 ng/mL-300 ng/mL，適用于科研領域中對猴模型（如食蟹猴、恒河猴等）的免疫學研究，例如評估疾病模型中補體系統的激活狀態、藥物或疫苗干預后免疫應答的動態變化，或體外實驗中細胞因子誘導的補體通路調控分析本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    C3Complement C3 [Cleaved into: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; C3-beta-c ELISA kit; C3bc); Acylation stimulating protein ELISA kit; ASP ELISA kit; C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Monkey
  • 樣本類型：
    serum, plasma, cell culture supernates
  • 檢測范圍：
    4.68 ng/mL-300 ng/mL
  • 靈敏度：
    1.17 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected  
    300 2.276 2.296 2.286 2.144  
    150 1.896 1.854 1.875 1.733  
    75 1.520 1.539 1.530 1.388  
    37.5 1.195 1.174 1.185 1.043  
    18.75 0.864 0.883 0.874 0.732  
    9.37 0.531 0.557 0.544 0.402  
    4.68 0.345 0.365 0.355 0.213  
    0 0.141 0.143 0.142 　  
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.; Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. In chronic inflammation, acts as a chemoattractant for neutrophils.; Acts as a chemoattractant for neutrophils in chronic inflammation.; adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-internalization and recycling of C5AR2.
  • 基因功能參考文獻：
    1. The structure of bovine C3 clearly demonstrates that the main chain around the thioester undergoes a helical transition upon activation, a rearrangement that is proposed to be the basis for the high level of reactivity of the thioester group. PMID: 16831446
  • 亞細胞定位：
    Secreted.
  • 數據庫鏈接：