Monkey Apolipoprotein(a) (LPA) ELISA kit

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產(chǎn)品詳情

產(chǎn)品描述：

猴載脂蛋白α(LPA)酶聯(lián)免疫試劑盒（CSB-EL013044RH）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的LPA含量。猴載脂蛋白α（LPA）是一種與心血管疾病風險相關的蛋白質(zhì)，其表達水平受基因調(diào)控。研究發(fā)現(xiàn)，LPA通過其特定的結構域與低密度脂蛋白（LDL）結合，形成脂蛋白(a)（Lp(a)），增加心血管疾病風險。目前，針對LPA的研究主要集中在開發(fā)能夠抑制其表達或阻斷其與LDL結合的藥物，以降低心血管疾病風險。試劑盒檢測范圍為31.25 ng/mL-2000 ng/mL，適用于靈長類動物模型中脂代謝調(diào)控、心血管疾病機制、藥物干預效果評估等基礎研究，為科研人員提供穩(wěn)定可靠的LPA蛋白表達水平分析工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
別名：

LPAApolipoprotein(a ELISA kit; Apo(a) ELISA kit; Lp(a) ELISA kit; EC 3.4.21.- ELISA kit; Fragment ELISA kit
縮寫：

Lp-α, LPA
Uniprot No.：

P14417
種屬：

Monkey
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

31.25 ng/mL-2000 ng/mL
靈敏度：

15.63 ng/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Cardiovascular
測定原理：

quantitative
測定方法：

Competitive

精密度：

Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

功能：

Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.
相關疾病：

Elevated plasma concentrations of apo(a) and its naturally occurring proteolytic fragments are correlated with atherosclerosis. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding.
蛋白家族：

Peptidase S1 family, Plasminogen subfamily
數(shù)據(jù)庫鏈接：

STRING: 9544.ENSMMUP00000021286

UniGene: Mmu.3290