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  4. Human Matrix metalloproteinase-21(MMP21) ELISA kit

Human Matrix metalloproteinase-21(MMP21) ELISA kit

  • 中文名稱：
    人基質(zhì)金屬蛋白酶-21(MMP21)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL014668HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 促銷：
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人基質(zhì)金屬蛋白酶-21(MMP21)酶聯(lián)免疫試劑盒（CSB-EL014668HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿樣本中的MMP21含量。MMP21 即基質(zhì)金屬蛋白酶 21，在胚胎發(fā)育、細胞遷移等生理過程有重要作用。其研究機制主要聚焦在酶活性調(diào)控、與底物相互作用方面。它的異常表達與腫瘤侵襲、轉(zhuǎn)移等病理過程相關(guān)，深入研究有助于為相關(guān)疾病治療提供新靶點。試劑盒檢測范圍為1.56 ng/mL-100 ng/mL，標(biāo)準(zhǔn)化流程適用于基礎(chǔ)研究中對MMP21表達水平的動態(tài)監(jiān)測，例如在細胞功能研究、疾病模型構(gòu)建或藥物干預(yù)實驗中評估該蛋白的生物學(xué)作用，為探索其在炎癥性疾病、纖維化或腫瘤進展中的機制提供數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    MMP21Matrix metalloproteinase-21 ELISA Kit; MMP-21 ELISA Kit; EC 3.4.24.- ELISA Kit
  • 縮寫：
    MMP21
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測范圍：
    1.56 ng/mL-100 ng/mL
  • 靈敏度：
    0.39 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin.
  • 基因功能參考文獻：
    1. MMP-21 572TT genotype increased the risk for the HIV-associated neurocognitive disorder. PMID: 29575199
    2. loss of MMP21 as a cause of heterotaxy in humans with concomitant defects in Notch signaling. PMID: 26429889
    3. Data show that MMP21 (encoding matrix metallopeptidase 21) point mutations were verified by Sanger sequencing, and segregation analysis indicated recessive inheritance. PMID: 26437028
    4. Increased MMP-21 expression in esophageal squamous cell carcinoma is associated with progression and lymph node metastasis. PMID: 25015395
    5. These results suggest that high MMP-21 expression in lymph node metastatic foci can be used to predict survival in OSCC patients with LNM PMID: 24700287
    6. analysis proved MMP-21 to be an independent prognostic factor for overall survival of gastric cancer patients PMID: 23275114
    7. MMP-21 expression is elevated in primary CRC and related to tumor invasion and metastasis. MMP-21 was also proved to be an independent prognostic factor for patients with stage II and stage III colorectal cancer. PMID: 21656525
    8. MMP-21 does not associate with invasion of squamous cell cancer but may be involved in keratinocyte differentiation. PMID: 19601983
    9. MMP-21 was expressed by Merkel cell carcinoma cells in 13/43 cases and in eight samples by stromal neutrophils. None of the samples with MMP-21-expressing neutrophils had metastasized to the lymph nodes PMID: 19921252
    10. The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression of breast cancer. PMID: 15015597
    11. MMP-21 is not a marker of invasiveness, but rather of differentiation, in pancreatic cancer PMID: 17873896
    12. MMP-21 may be an important protease in the terminal differentiation of keratinocytes PMID: 18633436
    13. A nonsynchronous polymorphism in the MMP-21 promoter does not significantly confer susceptibility to hepatocellular carcinoma in a southern Chinese population. PMID: 18768525

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  • 相關(guān)疾病：
    Heterotaxy, visceral, 7, autosomal (HTX7)
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M10A family
  • 組織特異性：
    Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14357

    OMIM: 608416

    KEGG: hsa:118856

    STRING: 9606.ENSP00000357798

    UniGene: Hs.314141