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  4. Recombinant Mouse Thrombopoietin protein (Thpo), partial (Active)

Recombinant Mouse Thrombopoietin protein (Thpo), partial (Active)

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  • 中文名稱：
    小鼠Thpo重組蛋白
  • 品名簡稱：
    Recombinant Mouse Thpo protein, partial (Active)
  • 貨號：
    CSB-AP003451MO
  • 說明書：
  • 規(guī)格：
    ￥2124
  • 圖片：
  • 其他：

產(chǎn)品詳情

  • 純度：
    >95% as determined by SDS-PAGE.
  • 內(nèi)毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human MO7e cells is less than 1.0 ng/ml, corresponding to a specific activity of >1.0x106 IU/mg.
  • 基因名：
  • Uniprot No.：
  • 別名：
    Thpo; Thrombopoietin; C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 來源：
    E.Coli
  • 分子量：
    18.7 kDa
  • 表達區(qū)域：
    22-195aa
  • 氨基酸序列
    SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF
  • 蛋白標簽：
    Tag-Free
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
  • 緩沖液：
    0.2 μm filtered PBS, pH 7.4, with 5% Trehalose ,lyophilized
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
  • 基因功能參考文獻：
    1. Increased TPO expression in HSCs following IL-11 exposure could be mimicked or blocked by inhibiting or overexpressing miR-204-5p, respectively... IL-11 promoted Hematopoietic stem cell engraftment in a mouse model of aplastic anemia an effect that was attenuated in cells overexpressing miR-204-5p. PMID: 29217821
    2. this study assessed the physiological source of thrombopoietin, a key cytokine required for maintaining hematopoietic stem cell . PMID: 29622652
    3. TPO and its receptor Mpl are dispensable for platelet survival in adult mice PMID: 27344013
    4. Furthermore, although the contribution of the TPO treated graft to long-term hematological engraftment was reduced, the TPO treated and untreated grafts both contributed significantly to long-term chimerism in vivo. PMID: 25137252
    5. TPO treatment also promoted the peripheral induction of Foxp3(+) Tregs in conjunction with elevated circulating TGF-beta levels. PMID: 25212676
    6. novel findings about aspects of TPO action on stem cells PMID: 25564715
    7. Mpl expression, but not Tpo, is fundamental in the development of JAK2V617F(+) myeloproliferative neoplasms PMID: 25339357
    8. Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. PMID: 25298035
    9. Megakaryocytes regulate cell cycle quiescence of hematopoietic stem cell through the production of thrombopoietin. PMID: 25451253
    10. IEX-1 has a role in activation of Erk and NF-kB pathways, which affects thrombopoietin-promoted NHEJ DNA repair in hematopoietic stem cells PMID: 24184684
    11. Findings establish that Clock regulates Thpo and Mpl expression in vivo, and demonstrate an important link between the body's circadian timing mechanisms and megakaryopoiesis. PMID: 22284746
    12. Signal transduction pathway of ERK1/2 participates in the activation of thrombopoietin in inflammatory injury of BV2 cells. PMID: 21507308
    13. The implication of Tpo as a mediator of neuronal damage in experimental pneumococcal meningitis is reported. PMID: 21149592
    14. Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice: interactive effect with thrombopoietin PMID: 12005542
    15. glycan domain of thrombopoietin acts in trans to enhance secretion of the hormone and other cytokines PMID: 12101178
    16. Thrombopoietin expands hematopoietic stem cells after transplantation PMID: 12163458
    17. p38 mitogen-activated protein kinase (MAPK) was responsible for the TPO-induced Hoxb4 elevation PMID: 12855555
    18. Mpl stimulation by TPO results in the activation of Lyn kinase, which appears to limit the proliferative response through a signaling cascade that regulates MAPK activity PMID: 14726379
    19. Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells PMID: 15254242
    20. mpl-tpo signaling pathways are negatively modulated by lnk PMID: 15337790
    21. is strongly proapoptotic in the brain, causing death of newly generated neurons through the Ras-extracellular signal-regulated kinase 1/2 pathway PMID: 15642952
    22. TPO(high) and GATA-1(low) alterations are linked in an upstream-downstream relationship along a pathobiologic pathway leading to development of myelofibrosis PMID: 15665119
    23. Development of myelofibrosis and osteosclerosis depends on local TPO levels in Bone marrow cells. PMID: 15927672
    24. Thrombopoietin synthesis is induced by IL-6 in the liver during acute inflammation. PMID: 16022585
    25. results suggest that a balance in positive and negative signals downstream from the TPO signal plays a role in the regulation of the probability of self-renewal in HSCs PMID: 17284614
    26. thrombopoietin has a role in mast cell differentiation [review] PMID: 17468237
    27. Chronic TPO overexpression induces mesangioproliferative glomerulopathy. PMID: 17546634
    28. roles for FAK in megakaryocyte growth and platelet function, setting the stage for manipulation of this component of the Tpo signaling apparatus for therapeutic benefit. PMID: 17925492
    29. Transcriptional regulation of bone marrow thrombopoietin by platelet proteins.( PMID: 18410987
    30. TPO induces HIF-1alpha expression in a manner very similar to that of hypoxia. PMID: 18473128
    31. thrombopoietin potentiates vasculogenesis by enhancing motility and enlivenment of transplanted endothelial progenitor cells via activation of Akt/mTOR/p70S6kinase signaling pathway PMID: 18773906
    32. TPO downmodulates c-Myb expression through induction of miR-150. PMID: 18814950

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    EPO/TPO family
  • 組織特異性：
    Found mainly in the liver, kidney and skeletal muscle.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:21832

    STRING: 10090.ENSMUSP00000075756

    UniGene: Mm.3943