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  4. Recombinant Mouse C-C motif chemokine 6 protein (Ccl6)

Recombinant Mouse C-C motif chemokine 6 protein (Ccl6)

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  • 中文名稱：
    Recombinant Mouse C-C motif chemokine 6 protein(Ccl6) (Active)
  • 品名簡稱：
    Recombinant Mouse Ccl6 protein (Active)
  • 貨號：
    CSB-AP001251MO
  • 說明書：
  • 規格：
    ￥2124
  • 圖片：
  • 其他：

產品詳情

  • 純度：
    >97% as determined by SDS-PAGE.
  • 內毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human CCR1 transfected murine BaF3 cells is in a concentration range of 10-100 ng/ml.
  • 基因名：
    Ccl6
  • Uniprot No.：
  • 別名：
    Ccl6; C10; Scya6C-C motif chemokine 6; Protein C10; Small-inducible cytokine A6) [Cleaved into: CCL6(22-95); CCL6(23-95)]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.Coli
  • 分子量：
    10.7 kDa
  • 表達區域：
    22-116aa
  • 氨基酸序列
    GLIQEIEKED RRYNPPIIHQ GFQDTSSDCC FSYATQIPCK RFIYYFPTSG GCIKPGIIFI SRRGTQVCAD PSDRRVQRCL STLKQGPRSG NKVIA
  • 蛋白標簽：
    Tag-Free
  • 產品提供形式：
    Liquid or Lyophilized powder
  • 緩沖液：
    Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM Tris, pH 8.0, 500 mM NaCl
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    CCL6(22-95) and CCL6(23-95) are potent chemoattractants.
  • 基因功能參考文獻：
    1. Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis. PMID: 20498053
    2. enhanced expression in intestinal epithelium following immunostimulation with LPS or pro-inflammatory cytokines PMID: 19812544
    3. the injury-induced expression of C10 at the mRNA and protein level PMID: 11895334
    4. c10 promotes fibrosis by recruiting macrophages in the inflammatory response to bleomycin in the lung PMID: 12356575
    5. CCL6 gene activation and production induced by SCF in the presence or absence of rather specific inhibitors for certain pathways demonstrated that the MEK/MAPK pathway but not the PI-3K pathway was crucial for the SCF-induced CCL6 gene activation. PMID: 17234680
    6. the chemokines CCL6 and CCL9 as genes prominently induced by the type I IFNs and ICSBP PMID: 19171873

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.
  • 數據庫鏈接：

    KEGG: mmu:20305

    STRING: 10090.ENSMUSP00000019071

    UniGene: Mm.137